Chapter title |
microRNA in Human Reproduction.
|
---|---|
Chapter number | 18 |
Book title |
microRNA: Medical Evidence
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-3-319-22671-2_18 |
Pubmed ID | |
Book ISBNs |
978-3-31-922670-5, 978-3-31-922671-2
|
Authors |
Eisenberg, Iris, Kotaja, Noora, Goldman-Wohl, Debra, Imbar, Tal, Iris Eisenberg, Noora Kotaja, Debra Goldman-Wohl, Tal Imbar |
Editors |
Gaetano Santulli |
Abstract |
microRNAs constitute a large family of approximately 21-nucleotide-long, noncoding RNAs. They emerged more than 20 years ago as key posttranscriptional regulators of gene expression. The regulatory role of these small RNA molecules has recently begun to be explored in the human reproductive system. microRNAs have been shown to play an important role in control of reproductive functions, especially in the processes of oocyte maturation, folliculogenesis, corpus luteum function, implantation, and early embryonic development. Knockout of Dicer, the cytoplasmic enzyme that cleaves the pre-miRNA to its mature form, results in postimplantation embryonic lethality in several animal models, attributing to these small RNA vital functions in reproduction and development. Another intriguing characteristic of microRNAs is their presence in body fluids in a remarkably stable form that is protected from endogenous RNase activity.In this chapter we will describe the current knowledge on microRNAs, specifically relating to human gonadal cells. We will focus on their role in the ovarian physiologic process and ovulation dysfunction, regulation of spermatogenesis and male fertility, and putative involvement in human normal and aberrant trophoblast differentiation and invasion through the process of placentation. |
X Demographics
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United States | 2 | 100% |
Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Chile | 1 | 3% |
Unknown | 29 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 17% |
Student > Master | 4 | 13% |
Student > Ph. D. Student | 3 | 10% |
Professor > Associate Professor | 3 | 10% |
Student > Postgraduate | 2 | 7% |
Other | 6 | 20% |
Unknown | 7 | 23% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 9 | 30% |
Medicine and Dentistry | 6 | 20% |
Agricultural and Biological Sciences | 5 | 17% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Psychology | 1 | 3% |
Other | 1 | 3% |
Unknown | 7 | 23% |