Chapter title |
microRNA and Autism.
|
---|---|
Chapter number | 5 |
Book title |
microRNA: Medical Evidence
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-3-319-22671-2_5 |
Pubmed ID | |
Book ISBNs |
978-3-31-922670-5, 978-3-31-922671-2
|
Authors |
Anitha, Ayyappan, Thanseem, Ismail, Ayyappan Anitha Ph.D., Ismail Thanseem Ph.D., Ayyappan Anitha, Ismail Thanseem |
Editors |
Gaetano Santulli |
Abstract |
Autism is a complex neurodevelopmental disorder characterized by deficiencies in social interaction and communication, and by repetitive and stereotyped behaviors. According to a recent report, the prevalence of this pervasive developmental disorder has risen to 1 in 88. This will have enormous public health implications in the future, and has necessitated the need to discover predictive biomarkers that could index for autism before the onset of symptoms. microRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression at the posttranscriptional level. They have recently emerged as prominent epigenetic regulators of various cellular processes including neurodevelopment. They are abundantly present in the brain, and their dysfunction has been implicated in an array of neuropathological conditions including autism. miRNAs, previously known to be expressed only in cells and tissues, have also been detected in extracellular body fluids such as serum, plasma, saliva, and urine. Altered expression of cellular and circulating miRNAs have been observed in autistic individuals compared to healthy controls. miRNAs are now being considered as potential targets for the development of novel therapeutic strategies for autism. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 64 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 13 | 20% |
Student > Ph. D. Student | 13 | 20% |
Student > Postgraduate | 5 | 8% |
Researcher | 4 | 6% |
Student > Bachelor | 4 | 6% |
Other | 9 | 14% |
Unknown | 16 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 15 | 23% |
Medicine and Dentistry | 10 | 16% |
Psychology | 5 | 8% |
Nursing and Health Professions | 5 | 8% |
Agricultural and Biological Sciences | 4 | 6% |
Other | 9 | 14% |
Unknown | 16 | 25% |