| Chapter title |
microRNA and Allergy.
|
|---|---|
| Chapter number | 17 |
| Book title |
microRNA: Medical Evidence
|
| Published in |
Advances in experimental medicine and biology, January 2015
|
| DOI | 10.1007/978-3-319-22671-2_17 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-922670-5, 978-3-31-922671-2
|
| Authors |
Rebane, Ana, Ana Rebane |
| Editors |
Gaetano Santulli |
| Abstract |
Allergy is a common hypersensitivity disorder of the immune system, which, along with other factors, is also subjected to regulation by microRNAs. The most common allergic diseases are allergic rhinitis, asthma, atopic dermatitis, and food allergy, which all are multifactorial and very heterogeneous conditions, highlighting the need for more individualized treatment techniques. More particular key questions in relation to allergic diseases are how microRNAs influence the differentiation, polarization, plasticity and functions of T helper and other immune cells, as well as the development of immune tolerance. In addition, microRNAs can affect allergic inflammation and tissue remodeling through their functions in epithelial and other tissue cells. Among immune system-related microRNAs, miR-21, miR-146a, and miR-155 are the most intensively studied and have convincingly been demonstrated to regulate immune responses and tissue inflammation in allergic diseases. Further characterization of microRNA functions is important, as similar to other conditions, the modulation of microRNA expression could potentially be used for therapeutic purposes in allergic diseases in the future. In addition, miRNAs could be implemented as biomarkers for endotyping complex allergic conditions. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Spain | 1 | 3% |
| Unknown | 29 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 26% |
| Student > Master | 4 | 13% |
| Student > Doctoral Student | 3 | 10% |
| Student > Bachelor | 3 | 10% |
| Student > Ph. D. Student | 3 | 10% |
| Other | 2 | 6% |
| Unknown | 8 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 19% |
| Agricultural and Biological Sciences | 6 | 19% |
| Biochemistry, Genetics and Molecular Biology | 4 | 13% |
| Immunology and Microbiology | 2 | 6% |
| Social Sciences | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 11 | 35% |