| Chapter title |
Transient Receptor Potential Channels and Itch: How Deep Should We Scratch?
|
|---|---|
| Chapter number | 6 |
| Book title |
Pharmacology of Itch
|
| Published in |
Handbook of experimental pharmacology, January 2015
|
| DOI | 10.1007/978-3-662-44605-8_6 |
| Pubmed ID | |
| Book ISBNs |
978-3-66-244604-1, 978-3-66-244605-8
|
| Authors |
Balázs I. Tóth, Arpad Szallasi, Tamás Bíró, Tóth, Balázs I., Szallasi, Arpad, Bíró, Tamás |
| Abstract |
Over the past 30 years, transient receptor potential (TRP) channels have evolved from a somewhat obscure observation on how fruit flies detect light to become the center of drug discovery efforts, triggering a heated debate about their potential as targets for therapeutic applications in humans. In this review, we describe our current understanding of the diverse mechanism of action of TRP channels in the itch pathway from the skin to the brain with focus on the peripheral detection of stimuli that elicit the desire to scratch and spinal itch processing and sensitization. We predict that the compelling basic research findings on TRP channels and pruritus will be translated into the development of novel, clinically useful itch medications. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 18 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 4 | 22% |
| Researcher | 4 | 22% |
| Student > Ph. D. Student | 2 | 11% |
| Student > Doctoral Student | 1 | 6% |
| Student > Bachelor | 1 | 6% |
| Other | 2 | 11% |
| Unknown | 4 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 39% |
| Biochemistry, Genetics and Molecular Biology | 2 | 11% |
| Engineering | 2 | 11% |
| Neuroscience | 2 | 11% |
| Psychology | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 3 | 17% |