Chapter title |
Neuraxial Opioid-Induced Itch and Its Pharmacological Antagonism.
|
---|---|
Chapter number | 17 |
Book title |
Pharmacology of Itch
|
Published in |
Handbook of experimental pharmacology, January 2015
|
DOI | 10.1007/978-3-662-44605-8_17 |
Pubmed ID | |
Book ISBNs |
978-3-66-244604-1, 978-3-66-244605-8
|
Authors |
Ko, Mei-Chuan, Mei-Chuan Ko |
Abstract |
Given its profound analgesic nature, neuraxial opioids are frequently used for pain management. Unfortunately, the high incident rate of itch/pruritus after spinal administration of opioid analgesics reported in postoperative and obstetric patients greatly diminishes patient satisfaction and thus the value of the analgesics. Many endeavors to solve the mystery behind neuraxial opioid-induced itch had not been successful, as the pharmacological antagonism other than the blockade of mu opioid receptors remains elusive. Nevertheless, as the characteristics of all opioid receptor subtypes have become more understood, more studies have shed light on the potential effective treatments. This review discusses the mechanisms underlying neuraxial opioid-induced itch and compares pharmacological evidence in nonhuman primates with clinical findings across diverse drugs. Both nonhuman primate and human studies corroborate that mixed mu/kappa opioid partial agonists seem to be the most effective drugs in ameliorating neuraxial opioid-induced itch while retaining neuraxial opioid-induced analgesia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 2% |
Unknown | 41 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 31% |
Student > Master | 5 | 12% |
Student > Doctoral Student | 4 | 10% |
Other | 3 | 7% |
Student > Postgraduate | 3 | 7% |
Other | 3 | 7% |
Unknown | 11 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 38% |
Neuroscience | 4 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Nursing and Health Professions | 3 | 7% |
Agricultural and Biological Sciences | 2 | 5% |
Other | 4 | 10% |
Unknown | 10 | 24% |