Chapter title |
Natural Phenolic Compounds as Therapeutic and Preventive Agents for Cerebral Amyloidosis.
|
---|---|
Chapter number | 4 |
Book title |
Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-3-319-18365-7_4 |
Pubmed ID | |
Book ISBNs |
978-3-31-918364-0, 978-3-31-918365-7
|
Authors |
Yamada, Masahito, Ono, Kenjiro, Hamaguchi, Tsuyoshi, Noguchi-Shinohara, Moeko, Masahito Yamada M.D., Ph.D., Kenjiro Ono, Tsuyoshi Hamaguchi, Moeko Noguchi-Shinohara, Masahito Yamada |
Editors |
Neville Vassallo |
Abstract |
Epidemiological studies have suggested that diets rich in phenolic compounds may have preventive effects on the development of dementia or Alzheimer's disease (AD). We investigated the effects of natural phenolic compounds, such as myricetin (Myr), rosmarinic acid (RA), ferulic acid (FA), curcumin (Cur) and nordihydroguaiaretic acid (NDGA) on the aggregation of amyloid β-protein (Aβ), using in vitro and in vivo models of cerebral Aβ amyloidosis. The in vitro studies revealed that these phenolic compounds efficiently inhibit oligomerization as well as fibril formation of Aβ through differential binding, whilst reducing Aβ oligomer-induced synaptic and neuronal toxicity. Furthermore, a transgenic mouse model fed orally with such phenolic compounds showed significant reduction of soluble Aβ oligomers as well as of insoluble Aβ deposition in the brain. These data, together with an updated review of the literature, indicate that natural phenolic compounds have anti-amyloidogenic effects on Aβ in addition to well-known anti-oxidative and anti-inflammatory effects, hence suggesting their potential as therapeutic and/or preventive agents for cerebral Aβ amyloidosis, including AD and cerebral amyloid angiopathy (CAA). Well-designed clinical trials or preventive interventions with natural phenolic compounds are necessary to establish their efficacy as disease-modifying agents. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 16% |
Student > Ph. D. Student | 6 | 14% |
Other | 4 | 9% |
Researcher | 4 | 9% |
Student > Bachelor | 3 | 7% |
Other | 9 | 20% |
Unknown | 11 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 16% |
Agricultural and Biological Sciences | 5 | 11% |
Chemistry | 4 | 9% |
Psychology | 3 | 7% |
Nursing and Health Professions | 2 | 5% |
Other | 8 | 18% |
Unknown | 15 | 34% |