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G Protein-Coupled Receptors - Modeling and Simulation

Overview of attention for book
Cover of 'G Protein-Coupled Receptors - Modeling and Simulation'

Table of Contents

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    Book Overview
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    Chapter 1 The GPCR Crystallography Boom: Providing an Invaluable Source of Structural Information and Expanding the Scope of Homology Modeling.
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    Chapter 2 Modeling of g protein-coupled receptors using crystal structures: from monomers to signaling complexes.
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    Chapter 3 Structure and dynamics of g-protein coupled receptors.
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    Chapter 4 How the Dynamic Properties and Functional Mechanisms of GPCRs Are Modulated by Their Coupling to the Membrane Environment
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    Chapter 5 Coarse-Grained Molecular Dynamics Provides Insight into the Interactions of Lipids and Cholesterol with Rhodopsin
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    Chapter 6 Beyond standard molecular dynamics: investigating the molecular mechanisms of g protein-coupled receptors with enhanced molecular dynamics methods.
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    Chapter 7 From Three-Dimensional GPCR Structure to Rational Ligand Discovery.
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    Chapter 8 Mathematical modeling of g protein-coupled receptor function: what can we learn from empirical and mechanistic models?
  10. Altmetric Badge
    Chapter 9 GPCR & Company: Databases and Servers for GPCRs and Interacting Partners.
  11. Altmetric Badge
    Chapter 10 Bioinformatics Tools for Predicting GPCR Gene Functions.
Attention for Chapter 9: GPCR & Company: Databases and Servers for GPCRs and Interacting Partners.
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Chapter title
GPCR & Company: Databases and Servers for GPCRs and Interacting Partners.
Chapter number 9
Book title
G Protein-Coupled Receptors - Modeling and Simulation
Published in
Advances in experimental medicine and biology, January 2014
DOI 10.1007/978-94-007-7423-0_9
Pubmed ID
24158806
Book ISBNs
978-9-40-077422-3, 978-9-40-077423-0
Authors

Noga Kowalsman, Masha Y Niv, Masha Y. Niv, Kowalsman, Noga, Niv, Masha Y.

Abstract

G-protein-coupled receptors (GPCRs) are a large superfamily of membrane receptors that are involved in a wide range of signaling pathways. To fulfill their tasks, GPCRs interact with a variety of partners, including small molecules, lipids and proteins. They are accompanied by different proteins during all phases of their life cycle. Therefore, GPCR interactions with their partners are of great interest in basic cell-signaling research and in drug discovery.Due to the rapid development of computers and internet communication, knowledge and data can be easily shared within the worldwide research community via freely available databases and servers. These provide an abundance of biological, chemical and pharmacological information.This chapter describes the available web resources for investigating GPCR interactions. We review about 40 freely available databases and servers, and provide a few sentences about the essence and the data they supply. For simplification, the databases and servers were grouped under the following topics: general GPCR-ligand interactions; particular families of GPCRs and their ligands; GPCR oligomerization; GPCR interactions with intracellular partners; and structural information on GPCRs. In conclusion, a multitude of useful tools are currently available. Summary tables are provided to ease navigation between the numerous and partially overlapping resources. Suggestions for future enhancements of the online tools include the addition of links from general to specialized databases and enabling usage of user-supplied template for GPCR structural modeling.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 33%
Professor 1 17%
Student > Ph. D. Student 1 17%
Student > Master 1 17%
Professor > Associate Professor 1 17%
Other 0 0%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 33%
Pharmacology, Toxicology and Pharmaceutical Science 1 17%
Chemistry 1 17%
Medicine and Dentistry 1 17%
Unknown 1 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2013.
All research outputs
#18,351,676
of 22,727,570 outputs
Outputs from Advances in experimental medicine and biology
#3,296
of 4,925 outputs
Outputs of similar age
#229,288
of 305,158 outputs
Outputs of similar age from Advances in experimental medicine and biology
#88
of 138 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,925 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,158 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 138 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.

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