Chapter title |
Modeling of g protein-coupled receptors using crystal structures: from monomers to signaling complexes.
|
---|---|
Chapter number | 2 |
Book title |
G Protein-Coupled Receptors - Modeling and Simulation
|
Published in |
Advances in experimental medicine and biology, January 2014
|
DOI | 10.1007/978-94-007-7423-0_2 |
Pubmed ID | |
Book ISBNs |
978-9-40-077422-3, 978-9-40-077423-0
|
Authors |
Angel Gonzalez, Arnau Cordomí, Minos Matsoukas, Julian Zachmann, Leonardo Pardo, Gonzalez, Angel, Cordomí, Arnau, Matsoukas, Minos, Zachmann, Julian, Pardo, Leonardo |
Abstract |
G protein-coupled receptors constitute a large and functionally diverse family of transmembrane proteins. They are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways and are among the most targeted proteins in drug discovery. Recent advances in crystallization methods have permitted to resolve the molecular structure of several members of the family. This chapter focuses on the impact of these structures in the use of homology modeling techniques for building three-dimensional models of homologous G protein-coupled receptors, higher order oligomers, and their complexes with ligands and signaling proteins. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 67% |
Ireland | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 50% |
Members of the public | 2 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 2 | 29% |
Student > Bachelor | 1 | 14% |
Student > Ph. D. Student | 1 | 14% |
Researcher | 1 | 14% |
Professor > Associate Professor | 1 | 14% |
Other | 0 | 0% |
Unknown | 1 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 3 | 43% |
Agricultural and Biological Sciences | 2 | 29% |
Biochemistry, Genetics and Molecular Biology | 1 | 14% |
Unknown | 1 | 14% |