Chapter title |
The Promise and Limitations of Anti-Inflammatory Agents for the Treatment of Major Depressive Disorder
|
---|---|
Chapter number | 26 |
Book title |
Inflammation-Associated Depression: Evidence, Mechanisms and Implications
|
Published in |
Current topics in behavioral neurosciences, June 2016
|
DOI | 10.1007/7854_2016_26 |
Pubmed ID | |
Book ISBNs |
978-3-31-951151-1, 978-3-31-951152-8
|
Authors |
Raison, Charles L, Charles L. Raison |
Editors |
Robert Dantzer, Lucile Capuron |
Abstract |
This review provides a critical perspective on recent meta-analyses suggesting that several anti-inflammatory modalities, including nonsteroidal anti-inflammatory drugs (NSAIDs), omega-3 fatty acids, and cytokine antagonist, possess generalizable antidepressant properties. By examining confounds and limitations in the available literature it is suggested that current data suggest that only a sub-group of individuals with major depressive disorder (MDD) have evidence of increased inflammatory biomarkers and it is in these individuals that anti-inflammatory agents show promise for reducing depressive symptoms. The treatment implications of this cautionary perspective are discussed. |
X Demographics
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United States | 3 | 18% |
United Kingdom | 2 | 12% |
France | 1 | 6% |
Unknown | 11 | 65% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 12 | 71% |
Scientists | 4 | 24% |
Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 66 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 16% |
Student > Bachelor | 10 | 15% |
Student > Ph. D. Student | 10 | 15% |
Student > Master | 9 | 13% |
Other | 3 | 4% |
Other | 5 | 7% |
Unknown | 19 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 25% |
Neuroscience | 7 | 10% |
Psychology | 7 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 9% |
Nursing and Health Professions | 2 | 3% |
Other | 5 | 7% |
Unknown | 23 | 34% |