Chapter title |
Absolute Values of Optical Properties (μa, μ΄s, μeff and DPF) of Human Head Tissue: Dependence on Head Region and Individual
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Chapter number | 52 |
Book title |
Oxygen Transport to Tissue XL
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Published in |
Advances in experimental medicine and biology, August 2018
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DOI | 10.1007/978-3-319-91287-5_52 |
Pubmed ID | |
Book ISBNs |
978-3-31-991285-1, 978-3-31-991287-5
|
Authors |
Felix Scholkmann, Hamoon Zohdi, Nassim Nasseri, Ursula Wolf, Scholkmann, Felix, Zohdi, Hamoon, Nasseri, Nassim, Wolf, Ursula |
Abstract |
Absolute optical properties (i.e., the absorption coefficient, μa, and the reduced scattering coefficient, [Formula: see text]) of head tissue can be measured with frequency-domain near-infrared spectroscopy (FD-NIRS). We investigated how the absolute optical properties depend on the individual subject and the head region. The data set used for the analysis comprised 31 single FD-NIRS measurements of 14 healthy subjects (9 men, 5 women, aged 33.4 ± 10.5 years). From an 8-min measurement (resting-state; FD-NIRS device: Imagent, ISS Inc.; bilateral over the prefrontal cortex, PFC, and visual cortex, VC) median values were calculated for μa and [Formula: see text] as well as the effective attenuation coefficient (μeff) and the differential pathlength factor (DPF). The measurement was done for each subject one to three times with at least 24 h between the measurements. (i) A Bayesian ANOVA analysis revealed that head region and subject were the most significant main effects on μa, [Formula: see text] and μeff, as well as DPF, respectively. (ii) At the VC, μa, [Formula: see text] and μeff had higher values compared to the PFC. (iii) The differences in the optical properties between PFC and VC were age-dependent. (iv) All optical properties also were age-dependent. This was strongest for the properties of the PFC compared to the VC. Our analysis demonstrates that all optical head tissue properties (μa, [Formula: see text], μeff and DPF) were dependent on the head region, individual subject and age. The optical properties of the head are like a 'fingerprint' for the individual subject. Assuming constant optical properties for the whole head should be carefully reconsidered. |
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