Chapter title |
Multispectral Near-Infrared Optical Tomography for Cancer Hypoxia Study in Mice
|
---|---|
Chapter number | 26 |
Book title |
Oxygen Transport to Tissue XL
|
Published in |
Advances in experimental medicine and biology, August 2018
|
DOI | 10.1007/978-3-319-91287-5_26 |
Pubmed ID | |
Book ISBNs |
978-3-31-991285-1, 978-3-31-991287-5
|
Authors |
A. Kalyanov, C. Germanier, L. Ahnen, J. Jiang, S. Lindner, A. Di Costanzo Mata, S. Sánchez Majos, M. Rudin, M. Wolf, Kalyanov, A., Germanier, C., Ahnen, L., Jiang, J., Lindner, S., Di Costanzo Mata, A., Sánchez Majos, S., Rudin, M., Wolf, M. |
Abstract |
Oxygenation of a tumor is one of the most important predictive factors: hypoxia is associated with aggressive tumors and substantially lower survival rate. Despite this high relevance of tumor oxygenation, there is currently no bedside technique available to measure it in clinical routine care. The aim of this work is to determine the oxygenation of tissue in mice by a continuous wave multispectral near-infrared optical tomograph (mNIROT). Tomographic reconstructions were processed by a massively modified NIRFAST software. We quantitatively measured the tissue oxygen saturation of the tumors in 4 BALB/c nude, female mice with human colon carcinoma cancer cells DLD-1 KRASwt injected subcutaneously. The study revealed changes of oxygenation in tumors on the long-term. |
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