Chapter title |
Use of a Turn Coil and Channel Above a GMR-SV Device to Observe and Measure the Properties of Deoxidized Red Blood Cells Coupled to Magnetic Beads
|
---|---|
Chapter number | 55 |
Book title |
Oxygen Transport to Tissue XL
|
Published in |
Advances in experimental medicine and biology, August 2018
|
DOI | 10.1007/978-3-319-91287-5_55 |
Pubmed ID | |
Book ISBNs |
978-3-31-991285-1, 978-3-31-991287-5
|
Authors |
Jong-Gu Choi, Su-Hee Kim, Sang-Suk Lee, Choi, Jong-Gu, Kim, Su-Hee, Lee, Sang-Suk |
Abstract |
A giant magnetoresistance-spin valve (GMR-SV) having highly sensitive magnetic properties was prepared with a multilayer soft ferromagnetic/non-magnetic/pinned ferromagnetic/anti-ferromagnetic iridium manganese (IrMn) top layer (NiFe/CoFe/Cu/CoFe/IrMn) structure. Micron-sized magnetic beads (MBs) with a diameter of 1 μm immersed in a solution containing 50 mg of Co-Si-OH/ml were attached to red blood cells (RBCs) having the very low magnetization of hemoglobin (HEM) to detect a deoxidized RBC combined with MBs (RBC+MBs). The RBC+MB combinations can be captured on a single-turn μ-coil that maintains a magnetic field large enough to detect the MBs attached to the RBC. When the RBC+MBs passes through a PR μ-channel with a width of 10 μm, its stopping and starting are controlled by the electrical AC input signal applied to the single-turn μ-coil. The RBC+MBs combinations captured above the μ-device of the GMR-SV change the output signal and thus, can be used for detection. This observation implies that this device can be used as a biosensor to analyze the coupling force between the HEM and the MBs for RBCs with deformed membranes passing through a narrow capillary. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 5 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 1 | 20% |
Researcher | 1 | 20% |
Student > Doctoral Student | 1 | 20% |
Unknown | 2 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Business, Management and Accounting | 1 | 20% |
Psychology | 1 | 20% |
Chemistry | 1 | 20% |
Unknown | 2 | 40% |