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Cancer Gene Profiling

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Attention for Chapter 10: Target Gene Discovery for Novel Therapeutic Agents in Cancer Treatment.
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Chapter title
Target Gene Discovery for Novel Therapeutic Agents in Cancer Treatment.
Chapter number 10
Book title
Cancer Gene Profiling
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3204-7_10
Pubmed ID
Book ISBNs
978-1-4939-3203-0, 978-1-4939-3204-7
Authors

Sanjay Tiwari Ph.D., Ole Ammerpohl Ph.D., Holger Kalthoff Ph.D., Sanjay Tiwari, Ole Ammerpohl, Holger Kalthoff

Editors

Robert Grützmann, Christian Pilarsky

Abstract

Target identification of novel therapeutic drugs is pivotal for the establishment of (1) new anticancer regiments, (2) to control side effects of the drugs, and (3) to identify appropriate combinations with established drugs.Here, we describe several in vitro assays applicable to characterize different characteristics of tumor cells. Furthermore, we present a protocol for establishing a reporter gene system for in vivo imaging, allowing for the study of drug effects in small animal models.