Chapter title |
Cancer Gene Profiling
|
---|---|
Chapter number | 6 |
Book title |
Cancer Gene Profiling
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3204-7_6 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3203-0, 978-1-4939-3204-7
|
Authors |
Shaw, Victoria, Bullock, Katie, Greenhalf, William, Victoria Shaw, Katie Bullock, William Greenhalf |
Editors |
Robert Grützmann, Christian Pilarsky |
Abstract |
Genetic heterogeneity explains variation in predisposition for cancer. Whole-genome analysis allows risk to be quantified, giving better targeted screening and quantification of the personalized risk posed by environmental factors. Array-based approaches to whole-genome analysis are rapidly being overtaken by next-generation sequencing (NGS). In this review the different platforms currently available for NGS are compared and the opportunities and risks of this approach are discussed: including the informatics packages required and the ethical issues. Methods applicable to the personal genome machine (PGM) are given as an example of workflows. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 20% |
Student > Ph. D. Student | 2 | 20% |
Student > Bachelor | 1 | 10% |
Other | 1 | 10% |
Professor | 1 | 10% |
Other | 0 | 0% |
Unknown | 3 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 30% |
Biochemistry, Genetics and Molecular Biology | 2 | 20% |
Computer Science | 1 | 10% |
Unknown | 4 | 40% |