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Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management

Overview of attention for book
Attention for Chapter 10: Personalized Radiation Therapy (PRT) for Lung Cancer.
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2 tweeters

Citations

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31 Mendeley
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Chapter title
Personalized Radiation Therapy (PRT) for Lung Cancer.
Chapter number 10
Book title
Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management
Published in
Advances in experimental medicine and biology, December 2015
DOI 10.1007/978-3-319-24932-2_10
Pubmed ID
Book ISBNs
978-3-31-924931-5, 978-3-31-924932-2
Authors

Jin, Jian-Yue, Kong, Feng-Ming Spring, Jian-Yue Jin Ph.D., Feng-Ming (Spring) Kong M.D., Ph.D., Jian-Yue Jin, Feng-Ming (Spring) Kong

Editors

Aamir Ahmad, Shirish M. Gadgeel

Abstract

This chapter reviews and discusses approaches and strategies of personalized radiation therapy (PRT) for lung cancers at four different levels: (1) clinically established PRT based on a patient's histology, stage, tumor volume and tumor locations; (2) personalized adaptive radiation therapy (RT) based on image response during treatment; (3) PRT based on biomarkers; (4) personalized fractionation schedule. The current RT practice for lung cancer is partially individualized according to tumor histology, stage, size/location, and combination with use of systemic therapy. During-RT PET-CT image guided adaptive treatment is being tested in a multicenter trial. Treatment response detected by the during-RT images may also provide a strategy to further personalize the remaining treatment. Research on biomarker-guided PRT is ongoing. The biomarkers include genomics, proteomics, microRNA, cytokines, metabolomics from tumor and blood samples, and radiomics from PET, CT, SPECT images. Finally, RT fractionation schedule may also be personalized to each individual patient to maximize therapeutic gain. Future PRT should be based on comprehensive considerations of knowledge acquired from all these levels, as well as consideration of the societal value such as cost and effectiveness.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 26%
Researcher 6 19%
Student > Doctoral Student 4 13%
Student > Master 4 13%
Student > Postgraduate 2 6%
Other 4 13%
Unknown 3 10%
Readers by discipline Count As %
Medicine and Dentistry 11 35%
Biochemistry, Genetics and Molecular Biology 3 10%
Social Sciences 2 6%
Agricultural and Biological Sciences 2 6%
Physics and Astronomy 1 3%
Other 6 19%
Unknown 6 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2015.
All research outputs
#6,370,771
of 8,394,790 outputs
Outputs from Advances in experimental medicine and biology
#1,492
of 2,526 outputs
Outputs of similar age
#216,707
of 315,893 outputs
Outputs of similar age from Advances in experimental medicine and biology
#341
of 629 outputs
Altmetric has tracked 8,394,790 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,526 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,893 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 629 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.