Chapter title |
Recent Advances in Helicobacter pylori Replication: Possible Implications in Adaptation to a Pathogenic Lifestyle and Perspectives for Drug Design
|
---|---|
Chapter number | 4 |
Book title |
Molecular Pathogenesis and Signal Transduction by Helicobacter pylori
|
Published in |
Current topics in microbiology and immunology, January 2017
|
DOI | 10.1007/978-3-319-50520-6_4 |
Pubmed ID | |
Book ISBNs |
978-3-31-950519-0, 978-3-31-950520-6
|
Authors |
Anna Zawilak-Pawlik, Jolanta Zakrzewska-Czerwińska |
Editors |
Nicole Tegtmeyer, Steffen Backert |
Abstract |
DNA replication is an important step in the life cycle of every cell that ensures the continuous flow of genetic information from one generation to the next. In all organisms, chromosome replication must be coordinated with overall cell growth. Helicobacter pylori growth strongly depends on its interaction with the host, particularly with the gastric epithelium. Moreover, H. pylori actively searches for an optimal microniche within a stomach, and it has been shown that not every microniche equally supports growth of this bacterium. We postulate that besides nutrients, H. pylori senses different, unknown signals, which presumably also affect chromosome replication to maintain H. pylori propagation at optimal ratio allowing H. pylori to establish a chronic, lifelong infection. Thus, H. pylori chromosome replication and particularly the regulation of this process might be considered important for bacterial pathogenesis. Here, we summarize our current knowledge of chromosome and plasmid replication in H. pylori and discuss the mechanisms responsible for regulating this key cellular process. The results of extensive studies conducted thus far allow us to propose common and unique traits in H. pylori chromosome replication. Interestingly, the repertoire of proteins involved in replication in H. pylori is significantly different to that in E. coli, strongly suggesting that novel factors are engaged in H. pylori chromosome replication and could represent attractive drug targets. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 17% |
Student > Bachelor | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Professor > Associate Professor | 2 | 11% |
Student > Master | 2 | 11% |
Other | 3 | 17% |
Unknown | 4 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 33% |
Immunology and Microbiology | 3 | 17% |
Medicine and Dentistry | 2 | 11% |
Environmental Science | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Other | 1 | 6% |
Unknown | 4 | 22% |