Chapter title |
Exploiting the Gastric Epithelial Barrier: Helicobacter pylori’s Attack on Tight and Adherens Junctions
|
---|---|
Chapter number | 9 |
Book title |
Molecular Pathogenesis and Signal Transduction by Helicobacter pylori
|
Published in |
Current topics in microbiology and immunology, January 2017
|
DOI | 10.1007/978-3-319-50520-6_9 |
Pubmed ID | |
Book ISBNs |
978-3-31-950519-0, 978-3-31-950520-6
|
Authors |
Steffen Backert, Thomas P. Schmidt, Aileen Harrer, Silja Wessler, Backert, Steffen, Schmidt, Thomas P., Harrer, Aileen, Wessler, Silja |
Editors |
Nicole Tegtmeyer, Steffen Backert |
Abstract |
Highly organized intercellular tight and adherens junctions are crucial structural components for establishing and maintenance of epithelial barrier functions, which control the microbiota and protect against intruding pathogens in humans. Alterations in these complexes represent key events in the development and progression of multiple infectious diseases as well as various cancers. The gastric pathogen Helicobacter pylori exerts an amazing set of strategies to manipulate these epithelial cell-to-cell junctions, which are implicated in changing cell polarity, migration and invasive growth as well as pro-inflammatory and proliferative responses. This chapter focuses on the H. pylori pathogenicity factors VacA, CagA, HtrA and urease, and how they can induce host cell signaling involved in altering cell-to-cell permeability. We propose a stepwise model for how H. pylori targets components of tight and adherens junctions in order to disrupt the gastric epithelial cell layer, giving fresh insights into the pathogenesis of this important bacterium. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 19% |
Student > Doctoral Student | 5 | 16% |
Student > Ph. D. Student | 5 | 16% |
Student > Bachelor | 4 | 13% |
Student > Master | 4 | 13% |
Other | 4 | 13% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 29% |
Immunology and Microbiology | 5 | 16% |
Veterinary Science and Veterinary Medicine | 3 | 10% |
Medicine and Dentistry | 3 | 10% |
Agricultural and Biological Sciences | 2 | 6% |
Other | 5 | 16% |
Unknown | 4 | 13% |