Chapter title |
SUMO and Chromatin Remodeling
|
---|---|
Chapter number | 3 |
Book title |
SUMO Regulation of Cellular Processes
|
Published in |
Advances in experimental medicine and biology, February 2017
|
DOI | 10.1007/978-3-319-50044-7_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-950043-0, 978-3-31-950044-7
|
Authors |
David Wotton, Lucy F. Pemberton, Jacqueline Merrill-Schools |
Editors |
Van G. Wilson |
Abstract |
Many of the known SUMO substrates are nuclear proteins, which regulate gene expression and chromatin dynamics. Sumoylation, in general, appears to correlate with decreased transcriptional activity, and in many cases modulation of the chromatin template is implicated. Sumoylation of the core histones is associated with transcriptional silencing, and transcription factor sumoylation can decrease gene expression by promoting recruitment of chromatin modifying enzymes. Additionally, sumoylation of transcriptional corepressors and chromatin remodeling enzymes can influence interactions with other transcriptional regulators, and alter their enzymatic activity. In some cases, proteins that are components of transcriptional corepressor complexes have been shown to be SUMO E3 ligases, further emphasizing the integration of sumoylation with the regulation of chromatin remodeling. Despite the evidence suggesting that sumoylation is primarily repressive for access to chromatin, recent analyses suggest that protein sumoylation on the chromatin template may play important roles at highly expressed genes. Elucidating the dynamic interplay of sumoylation with other post-translational modifications of histones and chromatin associated proteins will be key to fully understanding the regulation of access to the chromatin template. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 4 | 18% |
Student > Ph. D. Student | 3 | 14% |
Researcher | 3 | 14% |
Student > Bachelor | 2 | 9% |
Unknown | 10 | 45% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 18% |
Immunology and Microbiology | 3 | 14% |
Agricultural and Biological Sciences | 2 | 9% |
Chemistry | 2 | 9% |
Medicine and Dentistry | 1 | 5% |
Other | 0 | 0% |
Unknown | 10 | 45% |