| Chapter title |
Sumo Modification of Ion Channels
|
|---|---|
| Chapter number | 8 |
| Book title |
SUMO Regulation of Cellular Processes
|
| Published in |
Advances in experimental medicine and biology, February 2017
|
| DOI | 10.1007/978-3-319-50044-7_8 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-950043-0, 978-3-31-950044-7
|
| Authors |
Mark Benson, Jorge A. Iñiguez-lluhí, Jeffrey Martens, Benson, Mark, Iñiguez-lluhí, Jorge A., Martens, Jeffrey |
| Editors |
Van G. Wilson |
| Abstract |
Recently, a role for SUMO modification outside of the nucleus has emerged. Although the number of extranuclear proteins known to be sumoylated is comparatively small, ion channels represent one important new class of these proteins. Ion channels are responsible for the control of membrane excitability and therefore are critical for fundamental physiological processes such as muscle contraction, neuronal firing, and cellular homeostasis. As such, these ion-conducting proteins are subject to precise regulation. Recently, several studies have identified sumoylation as a novel mechanism of modulating ion channel function. These studies expand the list of known functions of sumoylation and reveal that, in addition to its more established role in the regulation of nuclear proteins, this modification plays important roles at the cytoplasmic face of membranes. |
Mendeley readers
Geographical breakdown
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|---|---|---|
| Mexico | 1 | 8% |
| Unknown | 11 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 25% |
| Student > Bachelor | 2 | 17% |
| Unspecified | 1 | 8% |
| Student > Doctoral Student | 1 | 8% |
| Student > Ph. D. Student | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 3 | 25% |
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|---|---|---|
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| Biochemistry, Genetics and Molecular Biology | 2 | 17% |
| Unspecified | 1 | 8% |
| Agricultural and Biological Sciences | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 3 | 25% |