Chapter title |
Introduction to Sumoylation
|
---|---|
Chapter number | 1 |
Book title |
SUMO Regulation of Cellular Processes
|
Published in |
Advances in experimental medicine and biology, February 2017
|
DOI | 10.1007/978-3-319-50044-7_1 |
Pubmed ID | |
Book ISBNs |
978-3-31-950043-0, 978-3-31-950044-7
|
Authors |
Van G. Wilson, Wilson, Van G. |
Editors |
Van G. Wilson |
Abstract |
Reversible post-translational modification is a rapid and efficient system to control the activity of pre-existing proteins. Modifiers range from small chemical moieties, such as phosphate groups, to proteins themselves as the modifier. The patriarch of the protein modifiers is ubiquitin which plays a central role in protein degradation and protein targeting. Over the last 20 years, the ubiquitin family has expanded to include a variety of ubiquitin-related small modifier proteins that are all covalently attached to a lysine residue on target proteins via series of enzymatic reactions. Of these more recently discovered ubiquitin-like proteins, the SUMO family has gained prominence as a major regulatory component that impacts numerous aspects of cell growth, differentiation, and response to stress. Unlike ubiquitinylation which often leads to proteins turn over, sumoylation performs a variety of function such as altering protein stability, modulating protein trafficking, directing protein-protein interactions, and regulating protein activity. This chapter will introduce the basic properties of SUMO proteins and the general tenets of sumoylation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 23% |
Student > Master | 5 | 9% |
Researcher | 5 | 9% |
Student > Bachelor | 4 | 8% |
Student > Postgraduate | 3 | 6% |
Other | 5 | 9% |
Unknown | 19 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 23% |
Agricultural and Biological Sciences | 9 | 17% |
Medicine and Dentistry | 4 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Immunology and Microbiology | 3 | 6% |
Other | 1 | 2% |
Unknown | 21 | 40% |