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The Molecular Biology of Down Syndrome

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Cover of 'The Molecular Biology of Down Syndrome'

Table of Contents

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    Book Overview
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    Chapter 1 Molecular abnormalities of the brain in Down Syndrome: relevance to Alzheimer’s neurodegeneration
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    Chapter 2 Reduced aldehyde dehydrogenase levels in the brain of patients with Down Syndrome
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    Chapter 3 The Down Syndrome critical region
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    Chapter 4 Neuropathology
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    Chapter 5 c-fos expression in brains of patients with Down Syndrome
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    Chapter 6 Neuronal cell death in Down’s syndrome
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    Chapter 7 Altered gene expression in fetal Down Syndrome brain as revealed by the gene hunting technique of subtractive hybridization
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    Chapter 8 Gene expression in fetal Down Syndrome brain as revealed by subtractive hybridization
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    Chapter 9 Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration
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    Chapter 10 Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down Syndrome and Alzheimer’s disease brain is downregulated at the mRNA and dysregulated at the protein level
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    Chapter 11 Gene expression relevant to Down Syndrome: problems and approaches
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    Chapter 12 Isolation and analysis of chromosome 21 genes potentially involved in Down Syndrome
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    Chapter 13 Differential display reveals deteriorated mRNA levels of NADH3 (complex I) in cerebellum of patients with Down Syndrome
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    Chapter 14 Serotonin (5-HT) in brains of adult patients with Down Syndrome
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    Chapter 15 Mechanisms of neuronal death in Down’s syndrome
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    Chapter 16 Impaired brain glucose metabolism in patients with Down Syndrome
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    Chapter 17 Oxidative stress and neural dysfunction in Down Syndrome
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    Chapter 18 Expression of the transcription factor ETS2 in brain of patients with Down Syndrome—evidence against the overexpression-gene dosage hypothesis
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    Chapter 19 Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down syndrome
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    Chapter 20 The “gene dosage effect” hypothesis versus the “amplified developmental instability” hypothesis in Down syndrome
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    Chapter 21 Downregulation of the transcription factor scleraxis in brain of patients with Down Syndrome
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    Chapter 22 Heat-shock protein 70 levels in brain of patients with Down Syndrome and Alzheimer’s disease
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    Chapter 23 Increased levels of 14-3-3 gamma and epsilon proteins in brain of patients with Alzheimer’s disease and Down Syndrome
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    Chapter 24 Application of Alu-splice PCR on chromosome 21: DSCR1 and Intersectin
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    Chapter 25 Overexpression of DNAse I in brain of patients with Down Syndrome
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Title
The Molecular Biology of Down Syndrome
Published by
Springer, Vienna, December 2013
DOI 10.1007/978-3-7091-6380-1
ISBNs
978-3-21-183377-3, 978-3-70-916380-1
Editors

G. Lubec

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 14%
Unknown 6 86%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 14%
Unknown 6 86%