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The Molecular Biology of Down Syndrome

Overview of attention for book
Cover of 'The Molecular Biology of Down Syndrome'

Table of Contents

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    Book Overview
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    Chapter 1 Molecular abnormalities of the brain in Down Syndrome: relevance to Alzheimer’s neurodegeneration
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    Chapter 2 Reduced aldehyde dehydrogenase levels in the brain of patients with Down Syndrome
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    Chapter 3 The Down Syndrome critical region
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    Chapter 4 Neuropathology
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    Chapter 5 c-fos expression in brains of patients with Down Syndrome
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    Chapter 6 Neuronal cell death in Down’s syndrome
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    Chapter 7 Altered gene expression in fetal Down Syndrome brain as revealed by the gene hunting technique of subtractive hybridization
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    Chapter 8 Gene expression in fetal Down Syndrome brain as revealed by subtractive hybridization
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    Chapter 9 Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration
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    Chapter 10 Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down Syndrome and Alzheimer’s disease brain is downregulated at the mRNA and dysregulated at the protein level
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    Chapter 11 Gene expression relevant to Down Syndrome: problems and approaches
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    Chapter 12 Isolation and analysis of chromosome 21 genes potentially involved in Down Syndrome
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    Chapter 13 Differential display reveals deteriorated mRNA levels of NADH3 (complex I) in cerebellum of patients with Down Syndrome
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    Chapter 14 Serotonin (5-HT) in brains of adult patients with Down Syndrome
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    Chapter 15 Mechanisms of neuronal death in Down’s syndrome
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    Chapter 16 Impaired brain glucose metabolism in patients with Down Syndrome
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    Chapter 17 Oxidative stress and neural dysfunction in Down syndrome.
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    Chapter 18 Expression of the transcription factor ETS2 in brain of patients with Down Syndrome—evidence against the overexpression-gene dosage hypothesis
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    Chapter 19 Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down syndrome
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    Chapter 20 The “gene dosage effect” hypothesis versus the “amplified developmental instability” hypothesis in Down syndrome
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    Chapter 21 Downregulation of the transcription factor scleraxis in brain of patients with Down Syndrome
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    Chapter 22 Heat-shock protein 70 levels in brain of patients with Down Syndrome and Alzheimer’s disease
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    Chapter 23 Increased levels of 14-3-3 gamma and epsilon proteins in brain of patients with Alzheimer’s disease and Down Syndrome
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    Chapter 24 Application of Alu-splice PCR on chromosome 21: DSCR1 and Intersectin
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    Chapter 25 Overexpression of DNAse I in brain of patients with Down Syndrome
Attention for Chapter 17: Oxidative stress and neural dysfunction in Down syndrome.
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Chapter title
Oxidative stress and neural dysfunction in Down syndrome.
Chapter number 17
Book title
The Molecular Biology of Down Syndrome
Published in
Journal of neural transmission Supplementum, January 1999
DOI 10.1007/978-3-7091-6380-1_17
Pubmed ID
10666681
Book ISBNs
978-3-21-183377-3, 978-3-70-916380-1
Authors

R C Iannello, P J Crack, J B de Haan, I Kola, Iannello, R C, Crack, P J, de Haan, J B, Kola, I, Iannello, R. C., Crack, P. J., Haan, J. B., Kola, I., R. C. Iannello, P. J. Crack, J. B. de Haan, I. Kola

Abstract

Total or partial trisomy of chromosome 21 occurs with relatively high frequency and is responsible for the occurrence of Down syndrome. Phenotypically, individuals with Down syndrome display characteristic morphological features and a variety of clinical disorders. One of the challenges for researchers in this field has been to ascertain and understand the relationship between the Down syndrome phenotype with the gene dosage effect resulting from trisomy of chromosome 21. Much attention therefore, has been given towards investigating the consequences of overexpressing chromosome 21-linked genes. In particular, an extensive analysis of SOD1 and APP have provided important insights as to how perturbations in the expression of their respective genes may contribute to the Down syndrome phenotype. In this review we will highlight studies which support a key role for SOD1 and APP in the pathogenesis of neural abnormalities observed in individuals with Down syndrome. Central to this relationship is how the redox state of the cell is affected and its consequences to neural function and integrity.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 15%
Student > Bachelor 4 15%
Professor > Associate Professor 4 15%
Student > Doctoral Student 3 11%
Student > Ph. D. Student 3 11%
Other 6 22%
Unknown 3 11%
Readers by discipline Count As %
Medicine and Dentistry 6 22%
Biochemistry, Genetics and Molecular Biology 6 22%
Agricultural and Biological Sciences 4 15%
Computer Science 2 7%
Neuroscience 2 7%
Other 4 15%
Unknown 3 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2018.
All research outputs
#17,704,678
of 22,733,113 outputs
Outputs from Journal of neural transmission Supplementum
#86
of 99 outputs
Outputs of similar age
#95,411
of 98,918 outputs
Outputs of similar age from Journal of neural transmission Supplementum
#3
of 3 outputs
Altmetric has tracked 22,733,113 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 99 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 98,918 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.

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