| Chapter title |
Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury
|
|---|---|
| Chapter number | 31 |
| Book title |
Mitochondrial Dynamics in Cardiovascular Medicine
|
| Published in |
Advances in experimental medicine and biology, May 2017
|
| DOI | 10.1007/978-3-319-55330-6_31 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-955329-0, 978-3-31-955330-6
|
| Authors |
Shin, Borami, Cowan, Douglas B., Emani, Sitaram M., del Nido, Pedro J., McCully, James D., Borami Shin MD, Douglas B. Cowan PhD, Sitaram M. Emani MD, Pedro J. del Nido MD, James D. McCully PhD, Borami Shin, Douglas B. Cowan, Sitaram M. Emani, Pedro J. del Nido, James D. McCully, Nido, Pedro J. |
| Editors |
Gaetano Santulli |
| Abstract |
Ischemic heart disease remains the leading cause of death worldwide. Mitochondria are the power plant of the cardiomyocyte, generating more than 95% of the cardiac ATP. Complex cellular responses to myocardial ischemia converge on mitochondrial malfunction which persists and increases after reperfusion, determining the extent of cellular viability and post-ischemic functional recovery. In a quest to ameliorate various points in pathways from mitochondrial damage to myocardial necrosis, exhaustive pharmacologic and genetic tools have targeted various mediators of ischemia and reperfusion injury and procedural techniques without applicable success. The new concept of replacing damaged mitochondria with healthy mitochondria at the onset of reperfusion by auto-transplantation is emerging not only as potential therapy of myocardial rescue, but as gateway to a deeper understanding of mitochondrial metabolism and function. In this chapter, we explore the mechanisms of mitochondrial dysfunction during ischemia and reperfusion, current developments in the methodology of mitochondrial transplantation, mechanisms of cardioprotection and their clinical implications. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 43 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 19% |
| Student > Ph. D. Student | 6 | 14% |
| Student > Bachelor | 5 | 12% |
| Other | 4 | 9% |
| Student > Master | 4 | 9% |
| Other | 5 | 12% |
| Unknown | 11 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 30% |
| Medicine and Dentistry | 11 | 26% |
| Neuroscience | 3 | 7% |
| Agricultural and Biological Sciences | 3 | 7% |
| Nursing and Health Professions | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 11 | 26% |