| Chapter title |
Functional Role of Mitochondria in Arrhythmogenesis
|
|---|---|
| Chapter number | 10 |
| Book title |
Mitochondrial Dynamics in Cardiovascular Medicine
|
| Published in |
Advances in experimental medicine and biology, May 2017
|
| DOI | 10.1007/978-3-319-55330-6_10 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-955329-0, 978-3-31-955330-6
|
| Authors |
Jessica Gambardella, Daniela Sorriento, Michele Ciccarelli, Carmine Del Giudice, Antonella Fiordelisi, Luigi Napolitano, Bruno Trimarco, Guido Iaccarino, Gaetano Santulli |
| Editors |
Gaetano Santulli |
| Abstract |
Growing evidence indicate that mitochondria play a functional role in arrhythmogenesis. We report here the molecular mechanisms underlying the action of these highly dynamic organelles in the regulation of cell metabolism, action potential and, overall, heart excitability. In particular, we examine the role of cardiac mitochondria in linking metabolism and cell excitability. The importance of the main mitochondrial channels is evaluated as well, including the recently identified calcium uniporter. Promises and pitfalls of potential therapeutic strategies targeting mitochondrial pathways are also assessed. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 16% |
| Researcher | 5 | 13% |
| Student > Master | 4 | 11% |
| Student > Bachelor | 4 | 11% |
| Professor > Associate Professor | 2 | 5% |
| Other | 3 | 8% |
| Unknown | 14 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 26% |
| Medicine and Dentistry | 7 | 18% |
| Agricultural and Biological Sciences | 3 | 8% |
| Neuroscience | 1 | 3% |
| Materials Science | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 15 | 39% |