| Chapter title |
Mitochondrial Calcium Handling in Physiology and Disease
|
|---|---|
| Chapter number | 2 |
| Book title |
Mitochondrial Dynamics in Cardiovascular Medicine
|
| Published in |
Advances in experimental medicine and biology, May 2017
|
| DOI | 10.1007/978-3-319-55330-6_2 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-955329-0, 978-3-31-955330-6
|
| Authors |
Veronica Granatiero, Diego De Stefani, Rosario Rizzuto |
| Editors |
Gaetano Santulli |
| Abstract |
Calcium (Ca(2+)) accumulation inside mitochondria represents a pleiotropic signal controlling a wide range of cellular functions, including key metabolic pathways and life/death decisions. This phenomenon has been first described in the 1960s, but the identity of the molecules controlling this process remained a mystery until just few years ago, when both mitochondrial Ca(2+) uptake and release systems were genetically dissected. This finally opened the possibility to develop genetic models to directly test the contribution of mitochondrial Ca(2+) homeostasis to cellular functions. Here we summarize our current understanding of the molecular machinery that controls mitochondrial Ca(2+) handling and critically evaluate the physiopathological role of mitochondrial Ca(2+) signaling, based on recent evidences obtained through in vitro and in vivo models. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 19% |
| Researcher | 8 | 15% |
| Student > Master | 6 | 11% |
| Student > Postgraduate | 3 | 6% |
| Student > Bachelor | 2 | 4% |
| Other | 9 | 17% |
| Unknown | 15 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 22 | 42% |
| Medicine and Dentistry | 4 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Unspecified | 2 | 4% |
| Neuroscience | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 17 | 32% |