Chapter title |
Mitochondria and Cardiac Hypertrophy
|
---|---|
Chapter number | 11 |
Book title |
Mitochondrial Dynamics in Cardiovascular Medicine
|
Published in |
Advances in experimental medicine and biology, May 2017
|
DOI | 10.1007/978-3-319-55330-6_11 |
Pubmed ID | |
Book ISBNs |
978-3-31-955329-0, 978-3-31-955330-6
|
Authors |
Heberty di Tarso Fernandes Facundo, Robert Eli Brainard, Francisco Rodrigo de Lemos Caldas, Aline Maria Brito Lucas |
Editors |
Gaetano Santulli |
Abstract |
Cardiac tissue responds to long-term hemodynamic load through initiation of a hypertrophic remodeling program. Importantly, if not counteracted this response will eventually lead to organ failure. Cardiac hypertrophic adaptations are complex, and involve multiple cellular events and the mechanisms underlying the development of cardiac hypertrophy are not well understood. Mitochondrial dysfunction has been indicated as a potential and important player in the development of cardiac hypertrophy. Additionally, substantial evidence shows that a significant portion of mitochondrial processes, necessary for normal cardiomyocyte physiology, are impacted by these hypertrophic changes. In this chapter, we will present and discuss the adaptations and changes in the mitochondrial electron transport system, mitochondrial metabolism, mitochondrial biogenesis, oxidative stress, the opening of the mitochondrial permeability transition pore following hypertrophic stimuli, as well as, review the various drugs (targeting mitochondria) that can be used in treatment of cardiac hypertrophy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 16% |
Student > Bachelor | 7 | 16% |
Student > Master | 6 | 13% |
Researcher | 5 | 11% |
Student > Doctoral Student | 2 | 4% |
Other | 5 | 11% |
Unknown | 13 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 20% |
Agricultural and Biological Sciences | 7 | 16% |
Medicine and Dentistry | 7 | 16% |
Nursing and Health Professions | 2 | 4% |
Unspecified | 1 | 2% |
Other | 2 | 4% |
Unknown | 17 | 38% |