Chapter title |
The Role of BTB-Zinc Finger Transcription Factors During T Cell Development and in the Regulation of T Cell-mediated Immunity.
|
---|---|
Chapter number | 374 |
Book title |
Transcriptional Control of Lineage Differentiation in Immune Cells
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Published in |
Current topics in microbiology and immunology, May 2014
|
DOI | 10.1007/82_2014_374 |
Pubmed ID | |
Book ISBNs |
978-3-31-907394-1, 978-3-31-907395-8
|
Authors |
Ellmeier W, Taniuchi I, Wilfried Ellmeier, Ichiro Taniuchi |
Editors |
Wilfried Ellmeier, Ichiro Taniuchi |
Abstract |
The proper regulation of the development and function of peripheral helper and cytotoxic T cell lineages is essential for T cell-mediated adaptive immunity. Progress made during the last 10-15 years led to the identification of several transcription factors and transcription factor networks that control the development and function of T cell subsets. Among the transcription factors identified are also several members of the so-called BTB/POZ domain containing zinc finger (ZF) transcription factor family (BTB-ZF), and important roles of BTB-ZF factors have been described. In this review, we will provide an up-to-date overview about the role of BTB-ZF factors during T cell development and in peripheral T cells. |
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