The Role of BTB-Zinc Finger Transcription Factors During T Cell Development and in the Regulation of T Cell-mediated Immunity.
Transcriptional Control of Lineage Differentiation in Immune Cells
Current topics in microbiology and immunology, May 2014
Ellmeier W, Taniuchi I, Wilfried Ellmeier, Ichiro Taniuchi
Wilfried Ellmeier, Ichiro Taniuchi
The proper regulation of the development and function of peripheral helper and cytotoxic T cell lineages is essential for T cell-mediated adaptive immunity. Progress made during the last 10-15 years led to the identification of several transcription factors and transcription factor networks that control the development and function of T cell subsets. Among the transcription factors identified are also several members of the so-called BTB/POZ domain containing zinc finger (ZF) transcription factor family (BTB-ZF), and important roles of BTB-ZF factors have been described. In this review, we will provide an up-to-date overview about the role of BTB-ZF factors during T cell development and in peripheral T cells.
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