Chapter title |
Mechanisms of Memory T Cell Activation and Effective Immunity
|
---|---|
Chapter number | 6 |
Book title |
Crossroads Between Innate and Adaptive Immunity V
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-3-319-15774-0_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-915773-3, 978-3-31-915774-0
|
Authors |
Grégoire Lauvau, Saïdi M’Homa Soudja |
Abstract |
Effective immunization induces the development of populations of robust effector lymphocytes specific for the immunizing antigens. Amongst them are cytotoxic/CD8(+)T lymphocytes, which few will further differentiate into long-lived memory cells persisting in the host and exhibiting improved functional characteristics. The current model is that such memory cells can confer rapid host protection upon cognate antigen-mediated activation and direct killing of infected cells. In this chapter, we discuss work from our group and others that highlight the contribution of inflammatory cytokines to memory CD8(+) T cell activation and of cytolysis-independent mechanisms of host protection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Comoros | 1 | 50% |
Japan | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
Unknown | 69 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 24% |
Student > Bachelor | 10 | 14% |
Researcher | 9 | 13% |
Student > Master | 8 | 11% |
Student > Doctoral Student | 5 | 7% |
Other | 9 | 13% |
Unknown | 13 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 14 | 20% |
Biochemistry, Genetics and Molecular Biology | 12 | 17% |
Agricultural and Biological Sciences | 7 | 10% |
Medicine and Dentistry | 6 | 8% |
Veterinary Science and Veterinary Medicine | 3 | 4% |
Other | 11 | 15% |
Unknown | 18 | 25% |