Chapter title |
Crossroads Between Innate and Adaptive Immunity V
|
---|---|
Chapter number | 7 |
Book title |
Crossroads Between Innate and Adaptive Immunity V
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-3-319-15774-0_7 |
Pubmed ID | |
Book ISBNs |
978-3-31-915773-3, 978-3-31-915774-0
|
Authors |
Beaulieu, Aimee M, Madera, Sharline, Sun, Joseph C, Aimee M. Beaulieu, Sharline Madera, Joseph C. Sun, Beaulieu, Aimee M., Sun, Joseph C. |
Abstract |
Immunological memory is a hallmark of the adaptive immune system. Although natural killer (NK) cells have traditionally been classified as a component of the innate immune system, they have recently been shown in mice and humans to exhibit certain features of immunological memory, including an ability to undergo a clonal-like expansion during virus infection, generate long-lived progeny (i.e. memory cells), and mediate recall responses against previously encountered pathogens-all characteristics previously ascribed only to adaptive immune responses by B and T cells in mammals. To date, the molecular events that govern the generation of NK cell memory are not completely understood. Using a mouse model of cytomegalovirus infection, we demonstrate that individual pro-inflammatory IL-12, IL-18, and type I-IFN signaling pathways are indispensible and play non-redundant roles in the generation of virus-specific NK cell memory. Furthermore, we discovered that antigen-specific proliferation and protection by NK cells is mediated by the transcription factor Zbtb32, which is induced by pro-inflammatory cytokines and promotes a cell cycle program in activated NK cells. A greater understanding of the molecular mechanisms controlling NK cell responses will provide novel strategies for tailoring vaccines to target infectious disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 4% |
Canada | 1 | 4% |
Unknown | 24 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 23% |
Researcher | 5 | 19% |
Student > Doctoral Student | 4 | 15% |
Student > Master | 4 | 15% |
Student > Bachelor | 2 | 8% |
Other | 3 | 12% |
Unknown | 2 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 27% |
Medicine and Dentistry | 5 | 19% |
Immunology and Microbiology | 5 | 19% |
Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Other | 1 | 4% |
Unknown | 3 | 12% |