Chapter title |
The Role of Il-12 and Type I Interferon in Governing the Magnitude of CD8 T Cell Responses
|
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Chapter number | 3 |
Book title |
Crossroads Between Innate and Adaptive Immunity V
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-3-319-15774-0_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-915773-3, 978-3-31-915774-0
|
Authors |
Gabriel R. Starbeck-Miller, John T. Harty, Starbeck-Miller, Gabriel R., Harty, John T. |
Abstract |
Antigen-specific CD8 T cells provide an important protective role in response to infection by viruses, intracellular bacteria, and parasites. Pathogen-specific CD8 T cells render this protection by undergoing robust expansion in numbers while gaining the ability to produce cytokines and cytolytic machinery. Creating optimal CD8 T cell responses to infection can be critical for raising sufficient armament to provide protection against invading intracellular pathogens. Although CD8 T cells have protective value, many vaccine strategies tend to focus on creating productive B cell antibody responses to promote immunological protection. Even though antibody responses can be highly protective, coupling optimal CD8 T cell responses with suboptimal B cell responses could provide higher orders of protection than either one on their own. Therefore, a deeper understanding of the pathways that ultimately guide the magnitude of CD8 T cell responses is required to explore this potential therapeutic benefit. The following chapter highlights our current understanding of how inflammatory cytokines regulate the magnitude of CD8 T cell responses. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
United States | 1 | 3% |
Unknown | 27 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 34% |
Student > Doctoral Student | 4 | 14% |
Professor | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Student > Bachelor | 2 | 7% |
Other | 4 | 14% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 13 | 45% |
Agricultural and Biological Sciences | 5 | 17% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Medicine and Dentistry | 2 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 4 | 14% |
Unknown | 2 | 7% |