Chapter title |
Syrian Hamsters as a Small Animal Model for Emerging Infectious Diseases: Advances in Immunologic Methods
|
---|---|
Chapter number | 135 |
Book title |
Emerging and Re-emerging Viral Infections
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/5584_2016_135 |
Pubmed ID | |
Book ISBNs |
978-3-31-952484-9, 978-3-31-952485-6
|
Authors |
Bryce M. Warner, David Safronetz, Gary P. Kobinger, Warner, Bryce M., Safronetz, David, Kobinger, Gary P. |
Abstract |
The use of small animal models for the study of infectious disease is critical for understanding disease progression and for developing prophylactic and therapeutic treatment options. For many diseases, Syrian golden hamsters have emerged as an ideal animal model due to their low cost, small size, ease of handling, and ability to accurately reflect disease progression in humans. Despite the increasing use and popularity of hamsters, there remains a lack of available reagents for studying hamster immune responses. Without suitable reagents for assessing immune responses, researchers are left to examine clinical signs and disease pathology. This becomes an issue for the development of vaccine and treatment options where characterizing the type of immune response generated is critical for understanding protection from disease. Despite the relative lack of reagents for use in hamsters, significant advances have been made recently with several hamster specific immunologic methods being developed. Here we discuss the progress of this development, with focus on classical methods used as well as more recent molecular methods. We outline what methods are currently available for use in hamsters and what is readily used as well as what limitations still exist and future perspectives of reagent and assay development for hamsters. This will provide valuable information to researchers who are deciding whether to use hamsters as an animal model. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 18% |
Researcher | 7 | 16% |
Student > Master | 7 | 16% |
Student > Bachelor | 4 | 9% |
Student > Doctoral Student | 2 | 4% |
Other | 1 | 2% |
Unknown | 16 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 18% |
Agricultural and Biological Sciences | 5 | 11% |
Immunology and Microbiology | 5 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 9% |
Medicine and Dentistry | 4 | 9% |
Other | 4 | 9% |
Unknown | 15 | 33% |