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Phosphodiesterases: CNS Functions and Diseases

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Cover of 'Phosphodiesterases: CNS Functions and Diseases'

Table of Contents

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    Book Overview
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    Chapter 1 Phosphodiesterase Diversity and Signal Processing Within cAMP Signaling Networks
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    Chapter 2 Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry
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    Chapter 3 Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases
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    Chapter 4 The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action
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    Chapter 5 Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-Related Metabolic Diseases
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    Chapter 6 From Age-Related Cognitive Decline to Alzheimer’s Disease: A Translational Overview of the Potential Role for Phosphodiesterases
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    Chapter 7 The Past, Present, and Future of Phosphodiesterase-4 Modulation for Age-Induced Memory Loss
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    Chapter 8 A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood
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    Chapter 9 Role of PDE9 in Cognition
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    Chapter 10 Regulation of Striatal Neuron Activity by Cyclic Nucleotide Signaling and Phosphodiesterase Inhibition: Implications for the Treatment of Parkinson’s Disease
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    Chapter 11 Role of Phosphodiesterases in Huntington’s Disease
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    Chapter 12 The Role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders
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    Chapter 13 Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction
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    Chapter 14 PDE Inhibitors for the Treatment of Schizophrenia
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    Chapter 15 Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence
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    Chapter 16 Genetic Understanding of Stroke Treatment: Potential Role for Phosphodiesterase Inhibitors
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    Chapter 17 A Unique Sub-Pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS
Attention for Chapter 9: Role of PDE9 in Cognition
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Chapter title
Role of PDE9 in Cognition
Chapter number 9
Book title
Phosphodiesterases: CNS Functions and Diseases
Published in
Advances in neurobiology, January 2017
DOI 10.1007/978-3-319-58811-7_9
Pubmed ID
28956335
Book ISBNs
978-3-31-958809-4, 978-3-31-958811-7
Authors

C. Dorner-Ciossek, K. S. Kroker, H. Rosenbrock

Abstract

Inhibition of phosphodiesterases (PDEs) has been demonstrated to enhance performance of animals in various cognition tasks and accordingly PDE inhibitors have been proposed as new approach for treatment of cognitive dysfunction (Reneerkens et al. Psychopharmacology 202:419-443, 2009; Schmidt Curr Top Med Chem 10(2):222-230, 2010). One of the eleven PDE isoforms, showing expression in cognition relevant brain regions across species, is PDE9, which hydrolyzes cGMP only. Furthermore, it is well established that the nitric oxide (NO)/cGMP pathway and NMDA receptor signaling has a crucial function in synaptic plasticity and cognitive function. In this chapter, we will provide an overview on PDE9, its expression and function in the brain, and hence, its relevance for synaptic plasticity and cognitive performance. Moreover, the recent advances of PDE9 inhibition as potential therapeutic approach for treatment of cognitive dysfunction in CNS disorders will be discussed.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 23%
Researcher 2 15%
Student > Bachelor 1 8%
Professor > Associate Professor 1 8%
Unknown 6 46%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 2 15%
Neuroscience 2 15%
Agricultural and Biological Sciences 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Unknown 7 54%

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