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Mendeley readers
| Chapter title |
A Unique Sub-Pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS
|
|---|---|
| Chapter number | 17 |
| Book title |
Phosphodiesterases: CNS Functions and Diseases
|
| Published in |
Advances in neurobiology, January 2017
|
| DOI | 10.1007/978-3-319-58811-7_17 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-958809-4, 978-3-31-958811-7
|
| Authors |
Yousheng Wang, Hengming Ke |
| Abstract |
This chapter describes crystal structures of phosphodiesterases (PDEs) that are involved in CNS diseases and their interactions with family selective inhibitors. The structural comparison identifies a small hydrophobic pocket next to the active site, which may be valuable for improvement of selectivity of PDE inhibitors. |
Mendeley readers
The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 6 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 1 | 17% |
| Researcher | 1 | 17% |
| Student > Postgraduate | 1 | 17% |
| Unknown | 3 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 33% |
| Agricultural and Biological Sciences | 1 | 17% |
| Unknown | 3 | 50% |