Chapter title |
Protein Structure Modeling with MODELLER
|
---|---|
Chapter number | 4 |
Book title |
Functional Genomics
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-7231-9_4 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7230-2, 978-1-4939-7231-9
|
Authors |
Benjamin Webb, Andrej Sali, Webb, Benjamin, Sali, Andrej |
Abstract |
Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized at atomic resolution using experimental structure determination methods. Computational protein structure modeling techniques have the potential to bridge this sequence-structure gap. In the following chapter, we present an example that illustrates the use of MODELLER to construct a comparative model for a protein with unknown structure. Automation of a similar protocol has resulted in models of useful accuracy for domains in more than half of all known protein sequences. |
Mendeley readers
Geographical breakdown
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Unknown | 199 | 100% |
Demographic breakdown
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Researcher | 28 | 14% |
Student > Master | 28 | 14% |
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Student > Doctoral Student | 14 | 7% |
Other | 31 | 16% |
Unknown | 38 | 19% |
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Other | 27 | 14% |
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