↓ Skip to main content

Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450

Overview of attention for book
Cover of 'Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Monooxygenase, Peroxidase and Peroxygenase Properties and Reaction Mechanisms of Cytochrome P450 Enzymes
  3. Altmetric Badge
    Chapter 2 Oxidizing Intermediates in P450 Catalysis: A Case for Multiple Oxidants
  4. Altmetric Badge
    Chapter 3 Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions.
  5. Altmetric Badge
    Chapter 4 Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1
  6. Altmetric Badge
    Chapter 5 Regioselective Versatility of Monooxygenase Reactions Catalyzed by CYP2B6 and CYP3A4: Examples with Single Substrates
  7. Altmetric Badge
    Chapter 6 Cytochrome P450 Enzymes in the Bioactivation of Polyunsaturated Fatty Acids and Their Role in Cardiovascular Disease.
  8. Altmetric Badge
    Chapter 7 Monooxygenation of Small Hydrocarbons Catalyzed by Bacterial Cytochrome P450s
  9. Altmetric Badge
    Chapter 8 Use of Chemical Auxiliaries to Control P450 Enzymes for Predictable Oxidations at Unactivated C-H Bonds of Substrates
  10. Altmetric Badge
    Chapter 9 Cytochrome P450 Enzymes and Electrochemistry: Crosstalk with Electrodes as Redox Partners and Electron Sources.
  11. Altmetric Badge
    Chapter 10 Mechanistic Basis of Electron Transfer to Cytochromes P450 by Natural Redox Partners and Artificial Donor Constructs
  12. Altmetric Badge
    Chapter 11 Biological Diversity of Cytochrome P450 Redox Partner Systems.
  13. Altmetric Badge
    Chapter 12 Cytochrome P450cin (CYP176A1)
  14. Altmetric Badge
    Chapter 13 Fungal Unspecific Peroxygenases: Heme-Thiolate Proteins That Combine Peroxidase and Cytochrome P450 Properties
Attention for Chapter 3: Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions.
Altmetric Badge

Citations

dimensions_citation
51 Dimensions

Readers on

mendeley
54 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions.
Chapter number 3
Book title
Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450
Published in
Advances in experimental medicine and biology, January 2015
DOI 10.1007/978-3-319-16009-2_3
Pubmed ID
Book ISBNs
978-3-31-916008-5, 978-3-31-916009-2
Authors

Sevrioukova, Irina F, Poulos, Thomas L, Irina F. Sevrioukova, Thomas L. Poulos

Abstract

Cytochrome P450 3A4 (CYP3A4) is the major and most important drug-metabolizing enzyme in humans that oxidizes and clears over a half of all administered pharmaceuticals. This is possible because CYP3A4 is promiscuous with respect to substrate binding and has the ability to catalyze diverse oxidative chemistries in addition to traditional hydroxylation reactions. Furthermore, CYP3A4 binds and oxidizes a number of substrates in a cooperative manner and can be both induced and inactivated by drugs. In vivo, CYP3A4 inhibition could lead to undesired drug-drug interactions and drug toxicity, a major reason for late-stage clinical failures and withdrawal of marketed pharmaceuticals. Owing to its central role in drug metabolism, many aspects of CYP3A4 catalysis have been extensively studied by various techniques. Here, we give an overview of experimental and theoretical methods currently used for investigation and prediction of CYP3A4-ligand interactions, a defining factor in drug metabolism, with an emphasis on the problems addressed and conclusions derived from the studies.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 28%
Student > Master 8 15%
Student > Bachelor 8 15%
Researcher 6 11%
Unspecified 4 7%
Other 5 9%
Unknown 8 15%
Readers by discipline Count As %
Chemistry 13 24%
Biochemistry, Genetics and Molecular Biology 11 20%
Pharmacology, Toxicology and Pharmaceutical Science 6 11%
Engineering 5 9%
Unspecified 4 7%
Other 9 17%
Unknown 6 11%