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Neurodegenerative Diseases

Overview of attention for book
Cover of 'Neurodegenerative Diseases'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Acuted Disseminated Encephalomyelitis
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    Chapter 2 Age-Related Macular Degeneration
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    Chapter 3 Arachnoid Cysts
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    Chapter 4 Autism Spectrum Disorders: Information for Pediatricians Supporting Families of Young Children on the Spectrum
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    Chapter 5 Autosomal Recessive Charcot-Marie-Tooth Neuropathy
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    Chapter 6 Creutzfeldt-Jakob disease.
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    Chapter 7 Epigenetics in autism and other neurodevelopmental diseases.
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    Chapter 8 Epilepsy and Epileptic Syndrome
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    Chapter 9 Frontotemporal Lobar Degeneration.
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    Chapter 10 Neurodegenerative Diseases
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    Chapter 11 Juvenile Neuronal Ceroid Lipofuscinoses
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    Chapter 12 Neurodegenerative Diseases
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    Chapter 13 Leukodystrophies
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    Chapter 14 Machado-Joseph Disease and other Rare Spinocerebellar Ataxias.
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    Chapter 15 Neurodegenerations induced by organophosphorous compounds.
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    Chapter 16 Mitochondrial Importance in Alzheimer’s, Huntington’s and Parkinson’s Diseases
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    Chapter 17 Multiple sclerosis.
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    Chapter 18 Myotonic Dystrophy Type 1 or Steinert’s Disease
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    Chapter 19 Neurodegeneration in diabetes mellitus.
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    Chapter 20 Neurofibromatoses
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    Chapter 21 Oxidative stress in developmental brain disorders.
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    Chapter 22 Oxidative Stress and Mitochondrial Dysfunction in Down Syndrome
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    Chapter 23 Pick’s Disease
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    Chapter 24 Premature Aging Syndrome
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    Chapter 25 The savant syndrome and its possible relationship to epilepsy.
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    Chapter 26 Sjogren-Larsson Syndrome
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    Chapter 27 The spinocerebellar ataxias: clinical aspects and molecular genetics.
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    Chapter 28 Tourette syndrome.
Attention for Chapter 15: Neurodegenerations induced by organophosphorous compounds.
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Chapter title
Neurodegenerations induced by organophosphorous compounds.
Chapter number 15
Book title
Neurodegenerative Diseases
Published in
Advances in experimental medicine and biology, March 2012
DOI 10.1007/978-1-4614-0653-2_15
Pubmed ID
Book ISBNs
978-1-4614-0652-5, 978-1-4614-0653-2

Hargreaves AJ, Alan J. Hargreaves


Organophosphorous compounds (OPs) are widely used in agriculture, industry and the home. Though best known for their acute effects when used as pesticides, which target acetylcholinesterase (AChE) activity in neuromuscular junctions and the central nervous system, not all OPs are potent inhibitors of this enzyme. The widespread use of OPs has heightened concern regarding their toxicity in man, with numerous reports linking OPs to various forms of delayed neuropathy encompassing a range of neurodegenerative, psychological and neurobehavioral effects. There is mounting evidence to suggest that sub-acute levels of OPs have the ability to interact directly with a range of target proteins in addition to AChE (i.e., noncholinergic targets), causing major disruption of membrane and protein turnover, protein phosphorylation, mitochondrial dysfunction, oxidative stress and cytoskeletal re-organisation, although the mechanisms involved are not fully understood. However, major advances have been made in the study of one OP binding protein neuropathy target esterase (NTE) in terms of its true physiological role. Additionally, there is increasing evidence for the ability of OPs to cause disruption in a number of metabolic and cell signalling pathways that affect neuronal cell proliferation, differentiation and survival and to interact direct with non-esterase proteins such as tubulin. The aim of this chapter is to review our current understanding of delayed neurotoxicity, to discuss how these molecular events may relate to each other and to suggest possible future directions in mechanistic studies of OP toxicity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 5%
Brazil 1 5%
Unknown 19 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 33%
Researcher 4 19%
Student > Doctoral Student 3 14%
Professor > Associate Professor 2 10%
Student > Master 2 10%
Other 3 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 29%
Medicine and Dentistry 4 19%
Chemistry 3 14%
Environmental Science 2 10%
Biochemistry, Genetics and Molecular Biology 2 10%
Other 3 14%
Unknown 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2012.
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Outputs from Advances in experimental medicine and biology
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Outputs of similar age from Advances in experimental medicine and biology
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Altmetric has tracked 4,506,977 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,315 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,140 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.