Report for: Heart Failure

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Chapter title	Wnt Signaling in Cardiac Remodeling and Heart Failure
Chapter number	56
Book title	Heart Failure
Published in	Handbook of experimental pharmacology, November 2016
DOI	10.1007/164_2016_56
Pubmed ID	27838851
Book ISBNs	978-3-31-959658-7, 978-3-31-959659-4
Authors	Stylianidis, Vasili, Hermans, Kevin C M, Blankesteijn, W Matthijs, Vasili Stylianidis, Kevin C. M. Hermans, W. Matthijs Blankesteijn
Abstract	Wnt signaling plays an essential role during development, but is also activated in diseases as diverse as neurodegeneration, osteoporosis, and cancer. Accumulating evidence demonstrates that Wnt signaling is also activated during cardiac remodeling and heart failure. In this chapter, we will provide a brief overview of Wnt signaling in all its complexity. Then we will discuss the evidence for its involvement in the development of cardiac hypertrophy, the wound healing after myocardial infarction (MI) and heart failure. Finally, we will provide an overview of the drugs that are available to target Wnt signaling at different levels of the signaling cascade and the results of these pharmacological interventions in cardiac disease.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.

Geographical breakdown

Country	Count	As %
Netherlands	1	100%

Demographic breakdown

Type	Count	As %
Members of the public	1	100%

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	31	100%

Demographic breakdown

Readers by professional status	Count	As %
Student > Bachelor	9	29%
Student > Doctoral Student	4	13%
Student > Ph. D. Student	3	10%
Lecturer	2	6%
Student > Master	2	6%
Other	4	13%
Unknown	7	23%

Readers by discipline	Count	As %
Medicine and Dentistry	10	32%
Biochemistry, Genetics and Molecular Biology	9	29%
Pharmacology, Toxicology and Pharmaceutical Science	1	3%
Engineering	1	3%
Unknown	10	32%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2017.

All research outputs

#18,510,888

of 22,931,367 outputs

Outputs from Handbook of experimental pharmacology

#503

of 646 outputs

Outputs of similar age

#234,026

of 308,796 outputs

Outputs of similar age from Handbook of experimental pharmacology

#12

of 19 outputs

Altmetric has tracked 22,931,367 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.

So far Altmetric has tracked 646 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.

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Heart Failure

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Geographical breakdown

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Attention Score in Context