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Heart Failure

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Cover of 'Heart Failure'

Table of Contents

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    Book Overview
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    Chapter 13 Direct Myosin Activation by Omecamtiv Mecarbil for Heart Failure with Reduced Ejection Fraction
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    Chapter 23 Mesenchymal Stem Cell Therapy for the Treatment of Heart Failure Caused by Ischemic or Non-ischemic Cardiomyopathy: Immunosuppression and Its Implications
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    Chapter 24 Heart Failure Guidelines on Pharmacotherapy
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    Chapter 25 Role of Hyperkalemia in Heart Failure and the Therapeutic Use of Potassium Binders
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    Chapter 27 Comorbidities in Heart Failure
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    Chapter 28 Vasopressin and Vasopressin Antagonists in Heart Failure
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    Chapter 30 Iron Deficiency Treatment in Patients with Heart Failure
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    Chapter 31 Cardiac Myosin Activation with Gene Therapy Produces Sustained Inotropic Effects and May Treat Heart Failure with Reduced Ejection Fraction
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    Chapter 55 Ivabradine.
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    Chapter 56 Wnt Signaling in Cardiac Remodeling and Heart Failure
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    Chapter 74 Epidemiology of Heart Failure
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    Chapter 75 Clinical Trial Design, Endpoints, and Regulatory Requirements
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    Chapter 76 Steroidal and Novel Non-steroidal Mineralocorticoid Receptor Antagonists in Heart Failure and Cardiorenal Diseases: Comparison at Bench and Bedside
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    Chapter 77 Sacubitril/Valsartan (LCZ696) in Heart Failure
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    Chapter 80 Platelet-Derived Growth Factor in Heart Failure
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    Chapter 81 Gene Therapy in Heart Failure
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    Chapter 82 Cardiac Phosphodiesterases and Their Modulation for Treating Heart Disease
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    Chapter 83 Partial Adenosine A1 Agonist in Heart Failure
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    Chapter 86 Biomarkers of Heart Failure with Preserved and Reduced Ejection Fraction
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    Chapter 88 New and Emerging Therapies and Targets: Beta-3 Agonists
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    Chapter 99 Noncoding RNAs in Heart Failure
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    Chapter 100 Novel sGC Stimulators and sGC Activators for the Treatment of Heart Failure
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    Chapter 101 The Three-Decade Long Journey in Heart Failure Drug Development
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    Chapter 123 Mitochondrial Therapies in Heart Failure
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    Chapter 126 Anticoagulation Therapy and NOACs in Heart Failure
Attention for Chapter 101: The Three-Decade Long Journey in Heart Failure Drug Development
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Chapter title
The Three-Decade Long Journey in Heart Failure Drug Development
Chapter number 101
Book title
Heart Failure
Published in
Handbook of experimental pharmacology, January 2016
DOI 10.1007/164_2016_101
Pubmed ID
Book ISBNs
978-3-31-959658-7, 978-3-31-959659-4
Authors

Kelly S. Lewis, Javed Butler, Johann Bauersachs, Peter Sandner

Abstract

Heart failure is a global disease with increasing prevalence due to an aging worldwide population with increasing co-morbidities. Despite several therapeutic options available to treat HFrEF, morbidity and mortality remain high. Importantly, no approved therapies are available to treat HFpEF. This paper will briefly summarize the burden of disease, HF classification and definitions and the landmark clinical trials in both HFrEF and HFpEF. Given the increasing incidence and prevalence of HF and the high morbidity and mortality associated with this disease, continued development efforts are essential to address the unmet needs of these patients.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 21%
Student > Ph. D. Student 4 14%
Student > Doctoral Student 2 7%
Researcher 2 7%
Student > Master 2 7%
Other 1 4%
Unknown 11 39%
Readers by discipline Count As %
Medicine and Dentistry 6 21%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Biochemistry, Genetics and Molecular Biology 1 4%
Unspecified 1 4%
Agricultural and Biological Sciences 1 4%
Other 3 11%
Unknown 14 50%