Report for: Oncogene-Induced Senescence

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Chapter title	Oncogene-Induced Senescence
Chapter number	16
Book title	Oncogene-Induced Senescence
Published in	Methods in molecular biology, January 2017
DOI	10.1007/978-1-4939-6670-7_16
Pubmed ID	27812878
Book ISBNs	978-1-4939-6668-4, 978-1-4939-6670-7
Authors	Nikiforov, Mikhail A, Shewach, Donna S, Mikhail A. Nikiforov, Donna S. Shewach, Nikiforov, Mikhail A., Shewach, Donna S.
Abstract	DNA damage response has been characterized as an important mediator of senescence phenotypes induced by activated oncogenes in normal human cells. Depletion of intracellular deoxyribonucleotide pools has been recently recognized as one of the major causes for DNA damage in these cells. Cells undergoing oncogene-induced senescence display decreased expression of several rate-limiting enzymes involved in the biosynthesis of deoxyribonucleotides, including thymidylate synthase (TS) and ribonucleotide reductase (RR). Individual depletion of these enzymes leads to premature senescence. Reciprocally, ectopic expression of TS and RR or addition of deoxyribonucleosides resulted in suppression of senescence phenotypes in normal or tumor cells caused by overexpression of activated HRAS or depletion of C-MYC, respectively. Therefore, in the current chapter, we will describe a methodology for the quantitative measurement of nucleotide pools in senescent cells.

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Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	5	100%

Demographic breakdown

Readers by professional status	Count	As %
Student > Master	2	40%
Student > Bachelor	1	20%
Student > Ph. D. Student	1	20%
Unknown	1	20%

Readers by discipline	Count	As %
Medicine and Dentistry	2	40%
Agricultural and Biological Sciences	1	20%
Unknown	2	40%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2016.

All research outputs

#20,351,881

of 22,899,952 outputs

Outputs from Methods in molecular biology

#9,922

of 13,134 outputs

Outputs of similar age

#355,310

of 420,444 outputs

Outputs of similar age from Methods in molecular biology

#845

of 1,074 outputs

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Oncogene-Induced Senescence

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Attention Score in Context