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Hypoxia and Exercise

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Cover of 'Hypoxia and Exercise'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 A Tribute to John Burden West
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    Chapter 2 Adventures in High-Altitude Physiology
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    Chapter 3 Exercise induced arterial hypoxemia: the role of ventilation-perfusion inequality and pulmonary diffusion limitation.
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    Chapter 4 Intrapulmonary Shunt During Normoxic and Hypoxic Exercise in Healthy Humans
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    Chapter 5 Exercise-induced arterial hypoxemia: consequences for locomotor muscle fatigue.
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    Chapter 6 Mechanisms of Sleep Apnea at Altitude
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    Chapter 7 Control of cerebral blood flow during sleep and the effects of hypoxia.
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    Chapter 8 Neural consequences of sleep disordered breathing: the role of intermittent hypoxia.
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    Chapter 9 Finding the Genes Underlying Adaptation to Hypoxia Using Genomic Scans for Genetic Adaptation and Admixture Mapping
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    Chapter 10 An Evolutionary Model for Identifying Genetic Adaptation to High Altitude
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    Chapter 11 Hypoxic Preconditioning and Erythropoietin Protect Retinal Neurons from Degeneration
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    Chapter 12 Blocking Stress Signaling Pathways with Cell Permeable Peptides
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    Chapter 13 JNK Pathway as Therapeutic Target to Prevent Degeneration in the Central Nervous System
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    Chapter 14 Salvage Of Ischemic Myocardium: A Focus on JNK
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    Chapter 15 Mitochondrial Reactive Oxygen Species are Required for Hypoxic HIFα Stabilization
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    Chapter 16 Hypoxia-Induced Gene Activity in Disused Oxidative Muscle
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    Chapter 17 Role of the Red Blood Cell in Nitric Oxide Homeostasis and Hypoxic Vasodilation
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    Chapter 18 Expression of the Heterotrimeric G Protein Gi and ATP Release are Impaired in Erythrocytes of Humans with Diabetes Mellitus
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    Chapter 19 Red Blood Cells and Hemoglobin in Hypoxic Pulmonary Vasoconstriction
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    Chapter 20 Dose-Response of Altitude Training: How Much Altitude is Enough?
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    Chapter 21 The eye at altitude.
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    Chapter 22 Lake Louise Consensus Methods for Measuring the Hypoxic Ventilatory Response
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    Chapter 23 Pulmonary Hypertension in High-Altitude Dwellers: Novel Mechanisms, Unsuspected Predisposing Factors
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    Chapter 24 Gene Hunting in Hypoxia and Exercise
Attention for Chapter 8: Neural consequences of sleep disordered breathing: the role of intermittent hypoxia.
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Chapter title
Neural consequences of sleep disordered breathing: the role of intermittent hypoxia.
Chapter number 8
Book title
Hypoxia and Exercise
Published in
Advances in experimental medicine and biology, January 2006
DOI 10.1007/978-0-387-34817-9_8
Pubmed ID
Book ISBNs
978-0-387-34816-2, 978-0-387-34817-9

Mary J. Morrell, Gillian Twigg


Sleep disordered breathing is characterised by periodic breathing, episodes of hypoxia and repeated arousals from sleep; symptoms include excessive daytime sleepiness, impairment of memory, learning and attention. Recent evidence from animal studies suggests that both intermittent hypoxia and sleep fragmentation can independently lead to neuronal defects in the hippocampus and pre frontal cortex; areas known to be closely associated with neural processing of memory and executive function. We have previously shown that sleep disordered breathing is associated with loss of gray matter concentration within the left hippocampus (47). We have now confirmed and extended this finding in 22 right handed, newly diagnosed male patients (mean (sd): age 51.8 (15.4) yrs, apnea/hypopnea index 53.1 (14.0) events/hr, minimum nocturnal oxygen saturation 75 (8.4) %) and 17 controls matched for age and handedness. Voxel-based morphometry, an automated unbiased technique, was used to characterise changes in gray matter concentration. The magnetic resonance images were segmented and grey matter concentration determined voxel by voxel. Analysis of variance was then preformed, adjusted for overall image intensity, with age as a covariant. Additional to the deficit in the left hippocampus, we found more extensive loss of gray matter bilaterally in the parahippocampus. No additional focal lesions were seen in other brain regions. Based on our findings and data from other human and animal studies, we speculate that in patients with sleep disordered breathing intermittent hypoxia is associated with neural deficit, and further that such lesions may lead to cognitive dysfunction.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 2 4%
Germany 1 2%
Unknown 44 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 19%
Student > Bachelor 6 13%
Student > Postgraduate 5 11%
Professor 4 9%
Researcher 4 9%
Other 9 19%
Unknown 10 21%
Readers by discipline Count As %
Psychology 14 30%
Medicine and Dentistry 10 21%
Agricultural and Biological Sciences 5 11%
Unspecified 2 4%
Computer Science 1 2%
Other 4 9%
Unknown 11 23%