Chapter title |
Type III interferons (IFNs): Emerging Master Regulators of Immunity
|
---|---|
Chapter number | 1 |
Book title |
Crossroads Between Innate and Adaptive Immunity V
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-3-319-15774-0_1 |
Pubmed ID | |
Book ISBNs |
978-3-31-915773-3, 978-3-31-915774-0
|
Authors |
Ioanna E. Galani, Ourania Koltsida, Evangelos Andreakos, Galani, Ioanna E., Koltsida, Ourania, Andreakos, Evangelos |
Abstract |
Lambda interferons (IFN-λs), type III interferons or interleukins 28 and 29 are the latest addition to the class II cytokine family. They share low homology with the interferon (IFN) and IL-10 cytokine families, yet they exhibit common and unique activities, the full spectrum of which still remains incompletely understood. Although initially described for their antiviral functions, it is now appreciated that IFN-λs also mediate diverse antitumor and immune-modulatory effects, and are key determinants of innate immunity at mucosal sites such as the gastrointestinal and respiratory tracks. Here, we are reviewing the biological functions of IFN-λs, the mechanisms controlling their expression, their downstream effects and their role in the maintenance of homeostasis and disease. We are also exploring the potential application of IFN-λs as novel therapeutics. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 63 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 23% |
Student > Bachelor | 9 | 14% |
Researcher | 7 | 11% |
Student > Doctoral Student | 7 | 11% |
Student > Master | 7 | 11% |
Other | 11 | 17% |
Unknown | 8 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 17 | 27% |
Immunology and Microbiology | 16 | 25% |
Agricultural and Biological Sciences | 11 | 17% |
Medicine and Dentistry | 8 | 13% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 1 | 2% |
Unknown | 10 | 16% |