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Experimental Models of Cardiovascular Diseases

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Cover of 'Experimental Models of Cardiovascular Diseases'

Table of Contents

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    Book Overview
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    Chapter 1 Experimental Models of Cardiovascular Diseases: Overview
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    Chapter 2 An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity
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    Chapter 3 Isolation of Atrial and Ventricular Cardiomyocytes for In Vitro Studies
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    Chapter 4 Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells
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    Chapter 5 Cardiomyocyte Differentiation from Human Embryonic Stem Cells
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    Chapter 6 Induction of Human Induced Pluripotent Stem Cells to Cardiomyocytes Using Embryoid Bodies
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    Chapter 7 Measuring Cardiomyocyte Contractility and Calcium Handling In Vitro
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    Chapter 8 Langendorff Perfusion Method as an Ex Vivo Model to Evaluate Heart Function in Rats
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    Chapter 9 Methods for the Preparation of an Excised, Cross-Circulated Rat Heart
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    Chapter 10 Optical Action Potential Mapping in Acute Models of Ischemia–Reperfusion Injury: Probing the Arrhythmogenic Role of the Mitochondrial Translocator Protein
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    Chapter 11 Cardiac Tissue Engineering Models of Inherited and Acquired Cardiomyopathies
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    Chapter 12 Badimon Perfusion Chamber: An Ex Vivo Model of Thrombosis
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    Chapter 13 Ischemic Model of Heart Failure in Rats and Mice
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    Chapter 14 Conventional Method of Transverse Aortic Constriction in Mice
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    Chapter 15 Characterization of the Differential Progression of Left Ventricular Remodeling in a Rat Model of Pressure Overload Induced Heart Failure. Does Clip Size Matter?
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    Chapter 16 Isoproterenol-Induced Heart Failure Mouse Model Using Osmotic Pump Implantation
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    Chapter 17 Rat Model of Cardiotoxic Drug-Induced Cardiomyopathy
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    Chapter 18 Pulmonary Artery Hypertension Model in Rats by Monocrotaline Administration
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    Chapter 19 The Sugen 5416/Hypoxia Mouse Model of Pulmonary Arterial Hypertension
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    Chapter 20 Mouse Model of Wire Injury-Induced Vascular Remodeling
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    Chapter 21 The Mouse Aortocaval Fistula Model with Intraluminal Drug Delivery
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    Chapter 22 A Pig Model of Myocardial Infarction: Catheter-Based Approaches
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    Chapter 23 Ovine Model of Ischemic Mitral Regurgitation
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    Chapter 24 Canine Model of Pacing-Induced Heart Failure
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    Chapter 25 Swine Model of Mitral Regurgitation Induced Heart Failure
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    Chapter 26 Pig Model of Increased Cardiac Afterload Induced by Ascending Aortic Banding
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    Chapter 27 Large Porcine Model of Profound Acute Ischemic Cardiogenic Shock
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    Chapter 28 Chronic Pulmonary Artery Embolization Models in Large Animals
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    Chapter 29 Modeling Pulmonary Hypertension: A Pig Model of Postcapillary Pulmonary Hypertension
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    Chapter 30 Development and Multiparametric Evaluation of Experimental Atherosclerosis in Rabbits
Attention for Chapter 8: Langendorff Perfusion Method as an Ex Vivo Model to Evaluate Heart Function in Rats
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Chapter title
Langendorff Perfusion Method as an Ex Vivo Model to Evaluate Heart Function in Rats
Chapter number 8
Book title
Experimental Models of Cardiovascular Diseases
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-8597-5_8
Pubmed ID
Book ISBNs
978-1-4939-8596-8, 978-1-4939-8597-5
Authors

Makino Watanabe, Takao Okada, Watanabe, Makino, Okada, Takao

Abstract

The Langendorff Perfused Heart Model is an experimental procedure developed at the end of the nineteenth century by Oskar Langendorff. In this procedure, an excised heart has a cannula inserted into its aorta so that the heart can be retrogradely perfused via the coronary artery. The procedure has been improved in recent times, and these improvements are used to evaluate the direct effect of medication on the heart as well as the effect of ischemia-reperfusion injury on heart function. In this chapter, we describe protocols for evaluating heart function in Langendorff perfused rat heart.

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Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 21%
Student > Master 10 17%
Researcher 5 9%
Student > Ph. D. Student 4 7%
Student > Postgraduate 3 5%
Other 4 7%
Unknown 20 34%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 19%
Medicine and Dentistry 9 16%
Agricultural and Biological Sciences 5 9%
Engineering 5 9%
Materials Science 2 3%
Other 2 3%
Unknown 24 41%