Chapter title |
Rat Model of Cardiotoxic Drug-Induced Cardiomyopathy
|
---|---|
Chapter number | 17 |
Book title |
Experimental Models of Cardiovascular Diseases
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-8597-5_17 |
Pubmed ID | |
Book ISBNs |
978-1-4939-8596-8, 978-1-4939-8597-5
|
Authors |
Takehiro Nakahara, Takashi Tanimoto, Artiom D. Petrov, Kiyotake Ishikawa, H. William Strauss, Jagat Narula, Nakahara, Takehiro, Tanimoto, Takashi, Petrov, Artiom D., Ishikawa, Kiyotake, Strauss, H. William, Narula, Jagat |
Abstract |
Cardiotoxicity from cancer drugs remains a clinical problem. To find reliable markers of cardiotoxicity, animal models were proposed and potential new diagnostic markers have been actively investigated using these models. Here we describe our protocols, using male Sprague-Dawley rats, for inducing cardiomyopathy by single injection of high-dose doxorubicin (5-10 mg/kg) or multiple injections (2-4 times) of low-dose doxorubicin (2.5 mg/kg) with combined single injection of trastuzumab (10 mg/kg). The cardiotoxicity is evaluated by imaging modalities (echocardiography and nuclear imaging), serum troponin levels, and histopathological analyses. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 25% |
Student > Doctoral Student | 2 | 10% |
Student > Bachelor | 2 | 10% |
Student > Master | 2 | 10% |
Professor | 1 | 5% |
Other | 3 | 15% |
Unknown | 5 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 15% |
Biochemistry, Genetics and Molecular Biology | 3 | 15% |
Agricultural and Biological Sciences | 3 | 15% |
Medicine and Dentistry | 3 | 15% |
Computer Science | 1 | 5% |
Other | 2 | 10% |
Unknown | 5 | 25% |