| Chapter title |
Notch and Stem Cells
|
|---|---|
| Chapter number | 12 |
| Book title |
Molecular Mechanisms of Notch Signaling
|
| Published in |
Advances in experimental medicine and biology, January 2018
|
| DOI | 10.1007/978-3-319-89512-3_12 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-989511-6, 978-3-31-989512-3
|
| Authors |
Anna Bigas, Cristina Porcheri |
| Abstract |
The Notch pathway is crucial in the regulation of stem cells biology. Notch-mediated signalling controls several aspects of tissue homeostasis in both embryonic and adult tissues, balancing stem cells maintenance and differentiation. Although the major elements of the pathway are well conserved throughout evolution, its fine regulation varies among different systems. In this review, we are focusing at the differences and analogies of Notch activity in different animal models, comparing stem cells of various tissues in both adulthood and development. We summarize the major mode of action of the Notch-pathway in dependency to the type of ligand, cross-talk control and transcriptional regulation adopted by stem cells to preserve their undifferentiation status or complete their maturation. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 20% |
| Student > Master | 2 | 13% |
| Student > Doctoral Student | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 8 | 53% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 20% |
| Agricultural and Biological Sciences | 2 | 13% |
| Immunology and Microbiology | 1 | 7% |
| Unknown | 9 | 60% |