Chapter title |
Endocytic Trafficking of the Notch Receptor
|
---|---|
Chapter number | 6 |
Book title |
Molecular Mechanisms of Notch Signaling
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-3-319-89512-3_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-989511-6, 978-3-31-989512-3
|
Authors |
Björn Schnute, Tobias Troost, Thomas Klein |
Abstract |
The endosomal pathway plays an important role in several aspects of Notch signalling ranging from ligand-dependent to independent activation and also degradation of the Notch receptor. Here, we will focus on its role during receptor degradation and describe the endosomal pathway with the components that are important for Notch degradation and the molecular machinery that orchestrates these events. Subsequently, we will describe the journey of Notch through the endosomal system and discuss the role of the genes involved. Mechanisms of the recently discovered ligand-independent activation of the Notch receptor in the endosomal pathway will be described and its contribution in physiologically Notch-dependent processes will be discussed. Last but not least, we will summarize the evidence for endosomal ligand-independent activation of the Notch pathway in vertebrates. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 24% |
Student > Ph. D. Student | 5 | 24% |
Researcher | 4 | 19% |
Other | 1 | 5% |
Student > Doctoral Student | 1 | 5% |
Other | 0 | 0% |
Unknown | 5 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 33% |
Agricultural and Biological Sciences | 6 | 29% |
Economics, Econometrics and Finance | 1 | 5% |
Medicine and Dentistry | 1 | 5% |
Neuroscience | 1 | 5% |
Other | 0 | 0% |
Unknown | 5 | 24% |