| Chapter title |
Mechanisms of Hematopoietic Stem Cell Ageing and Targets for Hematopoietic Tumour Prevention
|
|---|---|
| Chapter number | 8 |
| Book title |
Aging and Aging-Related Diseases
|
| Published in |
Advances in experimental medicine and biology, January 2018
|
| DOI | 10.1007/978-981-13-1117-8_8 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-131116-1, 978-9-81-131117-8
|
| Authors |
Min Liao, Jianwei Wang, Liao, Min, Wang, Jianwei |
| Abstract |
Hematopoietic stem cells represent a rare population in the bone marrow, with the capacity of generating all blood lineage and themselves at the same time. With aging, the reconstitution capacity of hematopoietic stem cells decreases accompanying with differentiation skewing wherein the myeloid branch dominates in both mouse and human. In recent years, various molecular mechanisms that induce functional decline of HSC during aging were disclosed including DNA damage accumulation, metabolic alteration, defects in protein homeostasis, and aging-induced changes in the blood circulatory environment. Deciphering the nature of HSC aging could improve our knowledge of HSC aging-related diseases and furthermore promote the developing of therapeutic interventions for human HSC aging and diseases. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 6 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Unspecified | 1 | 17% |
| Student > Bachelor | 1 | 17% |
| Other | 1 | 17% |
| Unknown | 3 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unspecified | 1 | 17% |
| Nursing and Health Professions | 1 | 17% |
| Agricultural and Biological Sciences | 1 | 17% |
| Unknown | 3 | 50% |