| Chapter title |
Intestinal Homeostasis and Longevity: Drosophila Gut Feeling
|
|---|---|
| Chapter number | 10 |
| Book title |
Aging and Aging-Related Diseases
|
| Published in |
Advances in experimental medicine and biology, January 2018
|
| DOI | 10.1007/978-981-13-1117-8_10 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-131116-1, 978-9-81-131117-8
|
| Authors |
Xiaolan Fan, Uma Gaur, Mingyao Yang, Fan, Xiaolan, Gaur, Uma, Yang, Mingyao |
| Abstract |
The association between intestinal homeostasis and life span has caught the attention of the research community worldwide. There have been multiple evidences which support the role of gut homeostasis in aging. The Drosophila gastrointestinal tract is very similar to the mammalian gut, and therefore it can directly be used as a model to understand the association between gut microbiota, immune system, and aging in humans. In current review we have discussed the importance of gut microbiota in aging. Also we have highlighted the importance of host immune system and gut aging. Since the increased microbial load in the gut activates the host immune system, the dysregulated microbiota can have direct implications in gut aging. The proliferation and renewal of intestinal stem cells can also affect gut aging. Another important aspect that we have discussed is the communication between the gut and the other organ systems which affect the overall aging process. Altogether we propose that the Drosophila gut can be a good model to improve our understanding of human gut aging. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 15% |
| Student > Bachelor | 3 | 12% |
| Researcher | 3 | 12% |
| Student > Ph. D. Student | 3 | 12% |
| Student > Doctoral Student | 2 | 8% |
| Other | 2 | 8% |
| Unknown | 9 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 27% |
| Immunology and Microbiology | 4 | 15% |
| Agricultural and Biological Sciences | 3 | 12% |
| Environmental Science | 2 | 8% |
| Medicine and Dentistry | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 9 | 35% |