Chapter title |
Pharmaceutical Intervention of Aging
|
---|---|
Chapter number | 15 |
Book title |
Aging and Aging-Related Diseases
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-981-13-1117-8_15 |
Pubmed ID | |
Book ISBNs |
978-9-81-131116-1, 978-9-81-131117-8
|
Authors |
Minxian Qian, Baohua Liu, Qian, Minxian, Liu, Baohua |
Abstract |
The aging population represents a significant worldwide socioeconomic challenge. Aging is an inevitable and multifactorial biological process and primary risk factor for most age-related diseases, such as cardiovascular diseases, cancers, type 2 diabetes mellitus (T2DM), and neurodegenerative diseases. Pharmacological interventions targeting aging appear to be a more effective approach in preventing age-related disorders compared with the treatments targeted to specific disease. In this chapter, we focus on the latest findings on molecular compounds that mimic caloric restriction (CR), supplement nicotinamide adenine dinucleotide (NAD+) levels, and eliminate senescent cells, including metformin, resveratrol, spermidine, rapamycin, NAD+ boosters, as well as senolytics. All these interventions modulate the determinants and pathways responsible for aging/longevity, such as the kinase target of rapamycin (TOR), AMP-activated protein kinase (AMPK), sirtuins, and insulin-like growth factor (IGF-1) signaling (Fig. 15.1). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
France | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 5 | 12% |
Student > Master | 4 | 10% |
Researcher | 4 | 10% |
Student > Bachelor | 3 | 7% |
Professor > Associate Professor | 3 | 7% |
Other | 8 | 19% |
Unknown | 15 | 36% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 14% |
Nursing and Health Professions | 4 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Agricultural and Biological Sciences | 1 | 2% |
Other | 5 | 12% |
Unknown | 17 | 40% |