Report for: Aging and Aging-Related Diseases

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Chapter title	Brain Aging: Hsp90 and Neurodegenerative Diseases
Chapter number	6
Book title	Aging and Aging-Related Diseases
Published in	Advances in experimental medicine and biology, January 2018
DOI	10.1007/978-981-13-1117-8_6
Pubmed ID	30232754
Book ISBNs	978-9-81-131116-1, 978-9-81-131117-8
Authors	Kun Wang, Yu Shang, Fei Dou, Wang, Kun, Shang, Yu, Dou, Fei
Abstract	The brain is the most complex organ in the human body and the main component of the central nervous system. Because it lacks the ability of regeneration, age is a major risk factor for most common neurodegenerative diseases, which caused an irreversible cognitive impairment. It has been shown that the function of molecular chaperones, majorly heat shock proteins, was compromised and then causes the imbalance of protein homeostasis inside the cell, which is the most influential reason of brain aging. Here, in this review, we discuss the mechanisms underneath the impairment of heat shock protein function during brain aging, including transcriptional regulation, posttranslational modification, and communication across cells and organs.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.

Geographical breakdown

Country	Count	As %
France	1	100%

Demographic breakdown

Type	Count	As %
Scientists	1	100%

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
United States	1	11%
Unknown	8	89%

Demographic breakdown

Readers by professional status	Count	As %
Student > Bachelor	2	22%
Unspecified	1	11%
Other	1	11%
Student > Ph. D. Student	1	11%
Researcher	1	11%
Other	1	11%
Unknown	2	22%

Readers by discipline	Count	As %
Agricultural and Biological Sciences	2	22%
Unspecified	1	11%
Biochemistry, Genetics and Molecular Biology	1	11%
Medicine and Dentistry	1	11%
Neuroscience	1	11%
Other	2	22%
Unknown	1	11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2018.

All research outputs

#18,649,666

of 23,103,903 outputs

Outputs from Advances in experimental medicine and biology

#3,336

of 4,976 outputs

Outputs of similar age

#330,932

of 442,720 outputs

Outputs of similar age from Advances in experimental medicine and biology

#154

of 237 outputs

Altmetric has tracked 23,103,903 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.

So far Altmetric has tracked 4,976 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,720 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.

We're also able to compare this research output to 237 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.

Aging and Aging-Related Diseases

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Demographic breakdown

Mendeley readers

Geographical breakdown

Demographic breakdown

Attention Score in Context