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Mendeley readers
Chapter title |
Protein Complex Production from the Drug Discovery Standpoint.
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Chapter number | 1 |
Book title |
Advanced Technologies for Protein Complex Production and Characterization
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Published in |
Advances in experimental medicine and biology, May 2016
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DOI | 10.1007/978-3-319-27216-0_1 |
Pubmed ID | |
Book ISBNs |
978-3-31-927214-6, 978-3-31-927216-0
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Authors |
Ismail Moarefi |
Editors |
M. Cristina Vega |
Abstract |
Small molecule drug discovery critically depends on the availability of meaningful in vitro assays to guide medicinal chemistry programs that are aimed at optimizing drug potency and selectivity. As it becomes increasingly evident, most disease relevant drug targets do not act as a single protein. In the body, they are instead generally found in complex with protein cofactors that are highly relevant for their correct function and regulation. This review highlights selected examples of the increasing trend to use biologically relevant protein complexes for rational drug discovery to reduce costly late phase attritions due to lack of efficacy or toxicity. |
Mendeley readers
The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 1 | 50% |
Student > Master | 1 | 50% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 50% |
Agricultural and Biological Sciences | 1 | 50% |